PMID- 8336490
OWN - NLM
STAT- MEDLINE
DCOM- 19930825
LR  - 20190512
IS  - 0146-4760 (Print)
IS  - 0146-4760 (Linking)
VI  - 17
IP  - 3
DP  - 1993 May-Jun
TI  - The determination of amphetamine and methamphetamine in a lyophilized human urine 
      reference material.
PG  - 165-70
AB  - The concentrations of amphetamine and methamphetamine in a new lyophilized human 
      urine reference material (RM) were determined at the National Institute of 
      Standards and Technology, in cooperation with the College of American 
      Pathologists. In order to minimize the possibility of undetected bias, two 
      different methods were developed. Both methods were based on isotope-dilution gas 
      chromatography/mass spectrometry (GC/MS) with a deuterium-labeled standard. The 
      first method used a solid phase extractor (SPE) to isolate the analytes, followed 
      by forming the heptafluorobutyryl (HFB) derivatives for measurement by GC/MS. The 
      second method used another kind of SPE to isolate the analytes, followed by 
      forming the N-trifluoroacetyl-1-prolyl chloride (TPC) derivatives for measurement 
      by GC/MS. The RM consists of three levels of amphetamine, three levels of 
      methamphetamine, and a blank. For amphetamine, the concentrations are 291, 558, 
      and 1081 ng/mL of human urine. For methamphetamine, the concentrations are 311, 
      573, and 1137 ng/mL of human urine.
FAU - Ellerbe, P
AU  - Ellerbe P
AD  - Organic Analytical Research Division, National Institute of Standards and 
      Technology, Technology Administration, Department of Commerce, Gaithersburg, MD 
      20899.
FAU - Long, T
AU  - Long T
FAU - Welch, M J
AU  - Welch MJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 0 (Solutions)
RN  - 44RAL3456C (Methamphetamine)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Amphetamine/*urine
MH  - Freeze Drying
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Isomerism
MH  - Methamphetamine/*urine
MH  - Reference Standards
MH  - Solutions
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
AID - 10.1093/jat/17.3.165 [doi]
PST - ppublish
SO  - J Anal Toxicol. 1993 May-Jun;17(3):165-70. doi: 10.1093/jat/17.3.165.