PMID- 8336945
OWN - NLM
STAT- MEDLINE
DCOM- 19930825
LR  - 20081121
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 8
IP  - 8
DP  - 1993 Aug
TI  - Evidence for stimulation of the transforming growth factor beta 1 promoter by 
      HIV-1 Tat in cells derived from CNS.
PG  - 2231-6
AB  - Infection by human immunodeficiency virus type 1 (HIV-1), the etiologic agent of 
      the acquired immunodeficiency syndrome (AIDS), is often complicated with a high 
      incidence of neurologic disorders. It is believed that HIV-1, in addition to 
      infecting both macroglial and microglial cells, may influence the expression of 
      several strategic genes of uninfected neighboring or latently infected brain 
      cells. It is suspected that the viral-encoded transregulatory protein, Tat, 
      facilitates cross-communications between these cells. In support of this concept, 
      earlier studies demonstrated that Tat is released from the infected cells, and 
      has the capacity to be taken up by the uninfected cells and exert its biological 
      activity on the responsive gene. Recent studies in several laboratories suggest 
      the involvement of Tat in altering the expression of a limited number of cellular 
      regulatory factors which, in turn, may mediate the altered physiology of the 
      cells. In this communication, we demonstrate the ability of the HIV-1 Tat protein 
      to increase expression of transforming growth factor beta 1 (TGF-beta 1), a 
      cytokine with potent immunosuppressive activity, in human astrocytic glial cells. 
      Implications of the Tat-mediated induction of TGF-beta 1 expression and cytokine 
      involvement in the regulation of immune response and central nervous system (CNS) 
      pathology are discussed.
FAU - Cupp, C
AU  - Cupp C
AD  - Jefferson Institute of Molecular Medicine, Department of Biochemistry and 
      Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
FAU - Taylor, J P
AU  - Taylor JP
FAU - Khalili, K
AU  - Khalili K
FAU - Amini, S
AU  - Amini S
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Gene Products, tat)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (tat Gene Products, Human Immunodeficiency Virus)
SB  - IM
MH  - Astrocytes/*drug effects/metabolism
MH  - Chromosome Mapping
MH  - Gene Expression/drug effects
MH  - Gene Products, tat/*pharmacology
MH  - *HIV-1
MH  - HeLa Cells
MH  - Humans
MH  - *Promoter Regions, Genetic
MH  - RNA, Messenger/analysis
MH  - Transcriptional Activation
MH  - Transforming Growth Factor beta/*genetics
MH  - Tumor Cells, Cultured
MH  - tat Gene Products, Human Immunodeficiency Virus
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
PST - ppublish
SO  - Oncogene. 1993 Aug;8(8):2231-6.