PMID- 8340997
OWN - NLM
STAT- MEDLINE
DCOM- 19930827
LR  - 20190817
IS  - 0047-1828 (Print)
IS  - 0047-1828 (Linking)
VI  - 57
IP  - 6
DP  - 1993 Jun
TI  - Cumulative effects of heart beat on ventricular premature contractions suggesting 
      possible involvement of triggered activity.
PG  - 503-11
AB  - We analyzed 24 h ECG recordings of 29 patients with frequent (> 2000/day) 
      ventricular premature contractions (VPCs) to evaluate: 1) the relationship 
      between VPC frequency and heart rate (HR); 2) the relationship between the 
      coupling interval (CI) of VPCs and HR; 3) the time course of changes in VPC 
      frequency following an abrupt and sustained increase in HR; and 4) the effect of 
      oral diltiazem (90 or 180 mg/day for 4 weeks) on VPCs. Based on the patterns of 
      relationship between VPC frequency and HR, patients were divided into 2 groups: 
      1) 17 patients with a positive correlation, the P group (a linear increase in 
      VPCs with increasing HRs); and 2) 12 patients with a non-positive correlation, 
      the NP group. The NP group showed either a linear decrease in VPCs with increased 
      HRs (4 patients) or an increase in VPCs at low HRs and a decrease at high HRs (8 
      patients). In all cases, an increased HR was associated with a shortening of CI. 
      In the P group, changes in VPCs after an abrupt increase in HR showed 2 types: 1) 
      delayed-ascent type, in which VPCs increased as the duration of HR increase was 
      prolonged (cumulative effects of heart beat) (7 patients); and non-delayed-ascent 
      type (10 patients). Diltiazem reduced VPCs > or = 75% in all of the 7 
      delayed-ascent-type patients, compared with 3 of the 10 non-delayed-ascent-type 
      patients (p < 0.05) and none of the 12 patients in the NP group (p < 
      0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Koumatsu, K
AU  - Koumatsu K
AD  - Department of Laboratory Medicine, Oita Medical University, Japan.
FAU - Ito, M
AU  - Ito M
FAU - Fujino, T
AU  - Fujino T
FAU - Saikawa, T
AU  - Saikawa T
FAU - Arita, M
AU  - Arita M
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn Circ J
JT  - Japanese circulation journal
JID - 7806868
RN  - EE92BBP03H (Diltiazem)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arrhythmias, Cardiac/drug therapy/*physiopathology
MH  - Diltiazem/therapeutic use
MH  - Electrocardiography
MH  - Female
MH  - Heart Rate/drug effects/*physiology
MH  - Heart Ventricles/drug effects/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/drug effects/*physiology
EDAT- 1993/06/01 00:00
MHDA- 1993/06/01 00:01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 1993/06/01 00:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
AID - 10.1253/jcj.57.503 [doi]
PST - ppublish
SO  - Jpn Circ J. 1993 Jun;57(6):503-11. doi: 10.1253/jcj.57.503.