PMID- 8341502
OWN - NLM
STAT- MEDLINE
DCOM- 19930830
LR  - 20220309
IS  - 0161-6420 (Print)
IS  - 0161-6420 (Linking)
VI  - 100
IP  - 8
DP  - 1993 Aug
TI  - The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis.
PG  - 1199-205
AB  - PURPOSE: To establish a human leukocyte antigen (HLA) association in a 
      homogeneous population of patients with pars planitis. METHODS: A strict set of 
      inclusion parameters was established for the diagnosis of pars planitis. Forty 
      patients with pars planitis who met these criteria underwent HLA analysis of 
      class I and II phenotypes. RESULTS: HLA-B8 was present in 15 (37.5%) of 40 
      patients versus 85 (19.7%) of 431 controls (relative risk, 2.44; P = 0.011). 
      HLA-B51 was present in 9 (22.5%) of 40 patients versus 51 (11.8%) of 431 controls 
      (relative risk, 2.16; P = 0.049). HLA-DR2 was present in 27 (67.5%) of 40 
      patients versus 121 (28.0%) of 431 controls (relative risk, 5.32; P < 0.0001). 
      HLA-DR2 has been associated with multiple sclerosis (MS). Exclusion of five 
      patients with pars planitis in whom MS subsequently developed did not change the 
      significance of these findings. CONCLUSIONS: The strongest association of pars 
      planitis with HLA-DR2 and the temporal development of MS in some patients with 
      pars planitis further supports an association between pars planitis and MS.
FAU - Malinowski, S M
AU  - Malinowski SM
AD  - Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City.
FAU - Pulido, J S
AU  - Pulido JS
FAU - Goeken, N E
AU  - Goeken NE
FAU - Brown, C K
AU  - Brown CK
FAU - Folk, J C
AU  - Folk JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B8 Antigen)
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DR2 Antigen)
SB  - IM
MH  - Case-Control Studies
MH  - Female
MH  - HLA-A Antigens/genetics
MH  - *HLA-B Antigens/genetics
MH  - HLA-B8 Antigen
MH  - HLA-D Antigens/genetics
MH  - *HLA-DR2 Antigen
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis/etiology/*immunology
MH  - Pars Planitis/complications/*immunology
MH  - Phenotype
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
AID - S0161-6420(93)31505-8 [pii]
AID - 10.1016/s0161-6420(93)31505-8 [doi]
PST - ppublish
SO  - Ophthalmology. 1993 Aug;100(8):1199-205. doi: 10.1016/s0161-6420(93)31505-8.