PMID- 8341689
OWN - NLM
STAT- MEDLINE
DCOM- 19930830
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 90
IP  - 14
DP  - 1993 Jul 15
TI  - Coexpression of neurotrophins and their receptors in neurons of the central 
      nervous system.
PG  - 6711-5
AB  - Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are 
      neuronal survival molecules which utilize the Trk family of tyrosine kinase 
      receptors. Using double-label in situ hybridization, we demonstrate that mRNAs 
      for BDNF and its high-affinity receptor TrkB are coexpressed in hippocampal and 
      cortical neurons. Also, a large number of neurons in these areas coexpress NGF 
      and BDNF mRNAs. Epileptic seizures lead to increased levels of both BDNF/TrkB and 
      NGF/BDNF mRNAs in double-labeled cells. Our results show that individual neurons 
      of the central nervous system can coexpress neurotrophins and their receptors and 
      produce two neurotrophic factors. These factors could support neuronal survival 
      after brain insults, not only via retrograde transport but also through autocrine 
      mechanisms.
FAU - Kokaia, Z
AU  - Kokaia Z
AD  - Department of Neurology, University Hospital, Lund, Sweden.
FAU - Bengzon, J
AU  - Bengzon J
FAU - Metsis, M
AU  - Metsis M
FAU - Kokaia, M
AU  - Kokaia M
FAU - Persson, H
AU  - Persson H
FAU - Lindvall, O
AU  - Lindvall O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain/cytology
MH  - Brain Chemistry
MH  - Brain-Derived Neurotrophic Factor
MH  - Cerebral Cortex/*chemistry/cytology
MH  - Hippocampus/*chemistry/cytology
MH  - In Situ Hybridization
MH  - Male
MH  - Membrane Proteins/*isolation & purification
MH  - Nerve Growth Factors/*isolation & purification
MH  - Nerve Tissue Proteins/*isolation & purification
MH  - Neurons/chemistry
MH  - RNA, Messenger/isolation & purification
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Seizures
PMC - PMC47002
EDAT- 1993/07/15 00:00
MHDA- 1993/07/15 00:01
PMCR- 1994/01/15
CRDT- 1993/07/15 00:00
PHST- 1993/07/15 00:00 [pubmed]
PHST- 1993/07/15 00:01 [medline]
PHST- 1993/07/15 00:00 [entrez]
PHST- 1994/01/15 00:00 [pmc-release]
AID - 10.1073/pnas.90.14.6711 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6711-5. doi: 
      10.1073/pnas.90.14.6711.