PMID- 8341924
OWN - NLM
STAT- MEDLINE
DCOM- 19930901
LR  - 20061115
IS  - 0035-2640 (Print)
IS  - 0035-2640 (Linking)
VI  - 43
IP  - 5
DP  - 1993 Mar 1
TI  - [Cytokines and inflammation].
PG  - 547-52
AB  - Numerous cytokines are present in inflammatory foci. Two of them, interleukin-1 
      (IL-1) and tumour necrosis factor (TNF), play a major role in coordinating 
      mechanisms which command inflammation. Under their action many cells produce 
      lipidic mediators, proteolytic enzymes or free radicals, all factors that are 
      directly responsible for the noxious effects observed. IL-1 and/or TNF exert 
      cytotoxic activities on vascular epithelium, cartilage, bone, muscle or beta 
      cells of pancreatic islets. Such cytokines as interferon gamma (IFN gamma), IL-3 
      or granulocyte-macrophage colony stimulating factor (GM-CSF) amplify the 
      inflammatory response by increasing the production of IL-1 and TNF by 
      macrophages. GM-CSF also produces other cytokines, such as IL-8 and the 
      macrophage chemoattractant protein 1 (MCP-1), the chemotactic properties of which 
      participate in the recruitment of leucocytes within the focus of inflammation. 
      IL-6 abounds in inflammatory processes and induces the production by hepatocytes 
      of acute inflammation phase proteins. The same applies to IL-1, TNF, IL-11, the 
      leukaemia inhibitory factor (LIF) or the transforming growth factor beta (TGF 
      beta). The latter also possesses a number of anti-inflammatory activities and, 
      like IL-4 and IL-10, can inhibit IL-1 and TNF production. Glucocorticoids have 
      this potential activity, and they may be produced by a cascade of events 
      initiated by IL-1, TNF and IL-6, involving the neuroendocrine system. The concept 
      of "cytokine network", therefore, perfectly illustrates the participation of 
      these mediators in inflammatory mechanisms.
FAU - Cavaillon, J M
AU  - Cavaillon JM
AD  - Unite d'immuno-allergie, Institut Pateur, Paris.
FAU - Haeffner-Cavaillon, N
AU  - Haeffner-Cavaillon N
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Cytokines et inflammation.
PL  - France
TA  - Rev Prat
JT  - La Revue du praticien
JID - 0404334
RN  - 0 (Cytokines)
MH  - Cytokines/*physiology
MH  - Humans
MH  - Inflammation/*physiopathology
RF  - 29
EDAT- 1993/03/01 00:00
MHDA- 1993/03/01 00:01
CRDT- 1993/03/01 00:00
PHST- 1993/03/01 00:00 [pubmed]
PHST- 1993/03/01 00:01 [medline]
PHST- 1993/03/01 00:00 [entrez]
PST - ppublish
SO  - Rev Prat. 1993 Mar 1;43(5):547-52.