PMID- 8343450
OWN - NLM
STAT- MEDLINE
DCOM- 19930907
LR  - 20120531
IS  - 0914-7470 (Print)
IS  - 0914-7470 (Linking)
VI  - 6
IP  - 1
DP  - 1993 Mar
TI  - [Detection of chromosomal numerical aberration in glioma by FISH (fluorescence in 
      situ hybridization)].
PG  - 62-5
AB  - FISH method with chromosome specific DNA probe to interphase nuclei has been 
      useful for the analysis of chromosomal numerical aberration in human brain tumor. 
      We applied the FISH method to 9 gliomas and one glioma cell line (KMU-100) with 4 
      kinds of chromosomes of number 7, 9, 10 and 17. The predominant specific 
      aberration in glioma were revealed the increased signal numbers of chromosome 
      7&17 and the decreased signal numbers of chromosome 9&10. The inactivation of 
      tumor suppressor genes and the activation of oncogenes have been suggested as the 
      principal mechanism of tumorigenesis in human cancer. The definite oncogenes have 
      not still been identified on chromosome 7&17 and tumor suppressor genes on 
      chromosome 9&10. We discussed the mechanism of tumorigenesis with one or more 
      oncogenes on chromosome 7&17 and of one or more tumor suppressor genes on 
      chromosome 9&10 in glioma.
FAU - Kasai, H
AU  - Kasai H
AD  - Department of Neurosurgery, Kansai Medical University, Moriguchi, Japan.
FAU - Imahori, T
AU  - Imahori T
FAU - Kawamoto, K
AU  - Kawamoto K
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Hum Cell
JT  - Human cell
JID - 8912329
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/*genetics
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 10
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 7
MH  - Chromosomes, Human, Pair 9
MH  - Female
MH  - Glioma/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
EDAT- 1993/03/01 00:00
MHDA- 1993/03/01 00:01
CRDT- 1993/03/01 00:00
PHST- 1993/03/01 00:00 [pubmed]
PHST- 1993/03/01 00:01 [medline]
PHST- 1993/03/01 00:00 [entrez]
PST - ppublish
SO  - Hum Cell. 1993 Mar;6(1):62-5.