PMID- 8353861
OWN - NLM
STAT- MEDLINE
DCOM- 19930923
LR  - 20220316
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 88
IP  - 3
DP  - 1993 Sep
TI  - Natriuretic peptide system in human heart failure.
PG  - 1004-9
AB  - BACKGROUND: Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), 
      and C-type natriuretic peptide (CNP) are a family of structurally related 
      peptides that participate in the integrated control of renal and cardiovascular 
      function. Previous studies suggest a functional role for these hormonal peptides 
      in cardiorenal regulation in congestive heart failure (CHF). METHODS AND RESULTS: 
      The present studies were performed in normal subjects (n = 6) and in patients 
      with mild (New York Heart Association [NYHA] class I to II, n = 20) and severe 
      (NYHA class III to IV, n = 20) CHF by use of radioimmunoassay and 
      immunohistochemical staining (IHCS). Plasma ANP was significantly increased in 
      both mild and severe CHF compared with normal subjects. In contrast, plasma BNP 
      was only moderately increased in the severe CHF group, and plasma CNP 
      concentration was unchanged in CHF compared with normal subjects. Atrial tissue 
      concentrations of the natriuretic peptides did not parallel circulating 
      concentrations. ANP predominated in normal atrial tissue, but BNP predominated in 
      CHF. In ventricular tissue, IHCS staining was present for all three peptides in 
      normal ventricular myocardium and was markedly enhanced in CHF. CONCLUSIONS: 
      These studies support a differential regulation of ANP, BNP, and CNP circulating 
      concentrations and tissue activity in human CHF.
FAU - Wei, C M
AU  - Wei CM
AD  - Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905.
FAU - Heublein, D M
AU  - Heublein DM
FAU - Perrella, M A
AU  - Perrella MA
FAU - Lerman, A
AU  - Lerman A
FAU - Rodeheffer, R J
AU  - Rodeheffer RJ
FAU - McGregor, C G
AU  - McGregor CG
FAU - Edwards, W D
AU  - Edwards WD
FAU - Schaff, H V
AU  - Schaff HV
FAU - Burnett, J C Jr
AU  - Burnett JC Jr
LA  - eng
GR  - HL-07111/HL/NHLBI NIH HHS/United States
GR  - HL-36634/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Nerve Tissue Proteins)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 127869-51-6 (Natriuretic Peptide, C-Type)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Atrial Natriuretic Factor/*analysis
MH  - Female
MH  - Heart Atria/chemistry
MH  - Heart Failure/*metabolism
MH  - Heart Ventricles/chemistry
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardium/chemistry
MH  - Natriuretic Peptide, Brain
MH  - Natriuretic Peptide, C-Type
MH  - Nerve Tissue Proteins/*analysis
MH  - Radioimmunoassay
EDAT- 1993/09/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
AID - 10.1161/01.cir.88.3.1004 [doi]
PST - ppublish
SO  - Circulation. 1993 Sep;88(3):1004-9. doi: 10.1161/01.cir.88.3.1004.