PMID- 8354693
OWN - NLM
STAT- MEDLINE
DCOM- 19930922
LR  - 20190508
IS  - 0021-9525 (Print)
IS  - 1540-8140 (Electronic)
IS  - 0021-9525 (Linking)
VI  - 122
IP  - 5
DP  - 1993 Sep
TI  - Neurotrophins and their receptors in rat peripheral trigeminal system during 
      maxillary nerve growth.
PG  - 1053-65
AB  - We examined the expression of the neurotrophins (NTFs) and their receptor mRNAs 
      in the rat trigeminal ganglion and the first branchial arch before and at the 
      time of maxillary nerve growth. The maxillary nerve appears first at embryonic 
      day (E)10 and reaches the epithelium of the first branchial arch at E12, as 
      revealed by anti-L1 immunohistochemistry. In situ hybridization demonstrates, 
      that at E10-E11, neurotrophin-3 (NT-3) mRNA is expressed mainly in the 
      mesenchyme, but neurotrophin-4 (NT-4) mRNA in the epithelium of the first 
      branchial arch. NGF and brain-derived neurotrophic factor (BDNF) mRNAs start to 
      be expressed in the distal part of the first brachial arch shortly before its 
      innervation by the maxillary nerve. Trigeminal ganglia strongly express the mRNA 
      of trkA at E10 and thereafter. The expression of mRNAs for low-affinity 
      neurotrophin receptor (LANR), trkB, and trkC in trigeminal ganglia is weak at 
      E10, but increases by E11-E12. NT-3, NT-4, and more prominently BDNF, induce 
      neurite outgrowth from explant cultures of the E10 trigeminal ganglia but no 
      neurites are induced by NGF, despite the expression of trkA. By E12, the 
      neuritogenic potency of NGF also appears. The expression of NT-3 and NT-4 and 
      their receptors in the trigeminal system prior to target field innervation 
      suggests that these NTFs have also other functions than being the target-derived 
      trophic factors.
FAU - Arumae, U
AU  - Arumae U
AD  - Laboratory of Molecular Neurobiology, University of Helsinki, Finland.
FAU - Pirvola, U
AU  - Pirvola U
FAU - Palgi, J
AU  - Palgi J
FAU - Kiema, T R
AU  - Kiema TR
FAU - Palm, K
AU  - Palm K
FAU - Moshnyakov, M
AU  - Moshnyakov M
FAU - Ylikoski, J
AU  - Ylikoski J
FAU - Saarma, M
AU  - Saarma M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Culture Techniques
MH  - Embryo, Mammalian/chemistry/innervation
MH  - Embryonic and Fetal Development
MH  - Female
MH  - In Situ Hybridization
MH  - Male
MH  - Maxillary Nerve/chemistry/*growth & development/physiology
MH  - Nerve Growth Factors/*analysis/genetics/physiology
MH  - Nerve Tissue Proteins/analysis/genetics/physiology
MH  - Neurotrophin 3
MH  - RNA, Messenger/analysis/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Nerve Growth Factor/*analysis/genetics/physiology
MH  - Trigeminal Ganglion/*chemistry/physiology/ultrastructure
PMC - PMC2119635
EDAT- 1993/09/01 00:00
MHDA- 1993/09/01 00:01
PMCR- 1994/03/01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 1993/09/01 00:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
PHST- 1994/03/01 00:00 [pmc-release]
AID - 93359503 [pii]
AID - 10.1083/jcb.122.5.1053 [doi]
PST - ppublish
SO  - J Cell Biol. 1993 Sep;122(5):1053-65. doi: 10.1083/jcb.122.5.1053.