PMID- 8355572
OWN - NLM
STAT- MEDLINE
DCOM- 19930921
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 53
IP  - 9
DP  - 1993
TI  - Recombinant interleukin-1 receptor antagonist protein prevents sensitization and 
      intestinal anaphylaxis in guinea pigs.
PG  - 733-8
AB  - Recombinant interleukin-1 receptor antagonist protein (rlRAP, 0.5 mg/kg) 
      administered intraperitoneally in guinea pigs one hour before primary and booster 
      parenteral sensitization (1 ml) by cow milk, led to a reduced immunoglobulin E 
      (IgE) production, as displayed by a passive cutaneous anaphylaxis test. rlRAP 
      administered intraperitoneally in sensitized guinea pigs at 0.5 mg/kg 10 min 
      before challenge administration (beta-lactoglobulin, 100 mg per os), also 
      prevents the colonic motor and secretory changes induced by intestinal 
      anaphylaxis. These results suggest the involvement of interleukin-1 in food 
      allergy and evidence a double protective role for rlRAP in food hypersensitivity.
FAU - Theodorou, V
AU  - Theodorou V
AD  - Department of Pharmacology, INRA, Toulouse, France.
FAU - Fioramonti, J
AU  - Fioramonti J
FAU - Bueno, L
AU  - Bueno L
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Antigens)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-1)
RN  - 0 (Lactoglobulins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Sialoglycoproteins)
SB  - IM
MH  - Anaphylaxis/immunology/*prevention & control
MH  - Animals
MH  - Antigens/immunology/pharmacology
MH  - Colon/drug effects/metabolism/physiology
MH  - Gastrointestinal Transit/drug effects/physiology
MH  - Guinea Pigs
MH  - *Immunization
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - Interleukin-1/therapeutic use
MH  - Intestinal Diseases/immunology/*prevention & control
MH  - Lactoglobulins/adverse effects
MH  - Male
MH  - Milk Hypersensitivity/immunology/prevention & control
MH  - Motor Activity/drug effects
MH  - Recombinant Proteins/therapeutic use
MH  - Sialoglycoproteins/*therapeutic use
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 0024-3205(93)90250-7 [pii]
AID - 10.1016/0024-3205(93)90250-7 [doi]
PST - ppublish
SO  - Life Sci. 1993;53(9):733-8. doi: 10.1016/0024-3205(93)90250-7.