PMID- 8355587
OWN - NLM
STAT- MEDLINE
DCOM- 19930921
LR  - 20190814
IS  - 0024-4201 (Print)
IS  - 0024-4201 (Linking)
VI  - 28
IP  - 7
DP  - 1993 Jul
TI  - The esterified plasma fatty acid profile is altered in early HIV-1 infection.
PG  - 593-7
AB  - Previous studies have shown that alterations in micronutrient utilization occur 
      in patients with Acquired Immune Deficiency Syndrome. In this study, total plasma 
      fatty acid composition was measured in 36 homosexual men infected with the Human 
      Immunodeficiency Virus 1 (HIV-1) and in 17 HIV-1 seronegative homosexual men in 
      order to evaluate differences associated with early HIV-1 infection. Immunologic 
      assessment included CD4 cell number count and lymphocyte blastogenesis in 
      response to the mitogens phytohemagglutinin (PHA) and pokeweed (PWM). The mean 
      total amount of omega 6 polyunsaturated fatty acids (18:2 and 20:4) was 
      significantly lower in the HIV-1 seropositive subjects (38 +/- 8.1% SD) as 
      compared to HIV-1 seronegative subjects (43 +/- 4.2%; P = 0.0027). This was also 
      reflected in a higher level of total saturated fatty acids (16:0 and 18:0) in 
      HIV-1 seropositive subjects (30 +/- 2.2% vs. 26 +/- 2.8%; P = 0.0001). The ratio 
      of linoleic to arachidonic acid (18:2 to 20:4) was higher in the HIV-1 
      seropositive group (6.76 +/- 4.88) compared to the HIV-1 seronegative group (4.86 
      +/- 1.37; P = 0.0213). The response to PHA in seropositive subjects correlated 
      inversely with total plasma omega 6 fatty acids (r = -0.36; P = 0.027), and 
      directly with the 18:2 to 20:4 ratio (r = 0.33; P = 0.046). CD4 cell counts and 
      the response to PWM did not correlate with plasma fatty acid levels in HIV-1 
      seropositive subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Peck, M D
AU  - Peck MD
AD  - Department of Surgery, University of Miami School of Medicine, Florida 33101.
FAU - Mantero-Atienza, E
AU  - Mantero-Atienza E
FAU - Miguez-Burbano, M J
AU  - Miguez-Burbano MJ
FAU - Lu, Y
AU  - Lu Y
FAU - Fletcher, M A
AU  - Fletcher MA
FAU - Shor-Posner, G
AU  - Shor-Posner G
FAU - Baum, M K
AU  - Baum MK
LA  - eng
GR  - 5-D43-TW00017-05/TW/FIC NIH HHS/United States
GR  - NIMH 1P50 MH42555/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Lipids
JT  - Lipids
JID - 0060450
RN  - 0 (Fatty Acids)
SB  - IM
EIN - Lipids 1993 Oct;28(10):961
MH  - Adult
MH  - CD4-CD8 Ratio
MH  - Fatty Acids/*blood
MH  - HIV Infections/immunology/*metabolism
MH  - *HIV-1
MH  - Humans
MH  - Leukocyte Count
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
AID - 10.1007/BF02536052 [doi]
PST - ppublish
SO  - Lipids. 1993 Jul;28(7):593-7. doi: 10.1007/BF02536052.