PMID- 8358109
OWN - NLM
STAT- MEDLINE
DCOM- 19930927
LR  - 20180216
IS  - 1018-8665 (Print)
IS  - 1018-8665 (Linking)
VI  - 187
IP  - 2
DP  - 1993
TI  - Is sustained production of tumor necrosis factor-alpha relevant to the 
      development of pustular psoriasis?
PG  - 81-3
AB  - Tumor necrosis factor-alpha (TNF-alpha) has been implicated as one of the 
      critical mediators of psoriasis. Evidence for an important role on the 
      progression of the disease is increasing, while recent clinical studies have 
      suggested its beneficial role in the disease. Based on the results of our 
      sequential analysis of the serum cytokine levels in a patient with pustular 
      psoriasis, we speculate that immunologic effects of constitutive local release of 
      TNF-alpha may be quite different from those of its systemic injection.
FAU - Sagawa, Y
AU  - Sagawa Y
AD  - Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.
FAU - Shiohara, T
AU  - Shiohara T
FAU - Imanishi, K
AU  - Imanishi K
FAU - Nagashima, M
AU  - Nagashima M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Switzerland
TA  - Dermatology
JT  - Dermatology (Basel, Switzerland)
JID - 9203244
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/blood
MH  - Humans
MH  - Interferon-gamma/blood
MH  - Interleukin-1/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Psoriasis/*immunology/therapy
MH  - Tumor Necrosis Factor-alpha/analysis/*biosynthesis
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1159/000247210 [doi]
PST - ppublish
SO  - Dermatology. 1993;187(2):81-3. doi: 10.1159/000247210.