PMID- 8361304
OWN - NLM
STAT- MEDLINE
DCOM- 19930927
LR  - 20131121
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 103
IP  - 9
DP  - 1993 Sep
TI  - The role of H2 antagonists in perennial allergic rhinitis.
PG  - 1013-9
AB  - The biological effects of anti-H2 in allergic reactions are dose dependent: low 
      doses enhance, and high doses significantly decrease the reaction of 
      hypersensitivity. The administration of cimetidine H2 antagonist to 20 perennial 
      allergic rhinitis patients brought about an abatement in the symptoms and a 
      decrease in the total serum immunoglobulin E (IgE) levels in 72% of treated 
      patients, but no variation was perceived in placebo-treated patients. These 
      results strengthen the hypothesis of anti-H2-induced immunoregulatory effects and 
      suggest a possible way of inhibiting IgE synthesis in vivo.
FAU - Testa, B
AU  - Testa B
AD  - Institute of Otolaryngology, School of Medicine, University of Naples, Italy.
FAU - Mesolella, C
AU  - Mesolella C
FAU - Filippini, P
AU  - Filippini P
FAU - Campagnano, N
AU  - Campagnano N
FAU - Testa, D
AU  - Testa D
FAU - Mesolella, M
AU  - Mesolella M
FAU - Sagnelli, E
AU  - Sagnelli E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 0 (Immunoglobulins)
RN  - 0 (Placebos)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 80061L1WGD (Cimetidine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cimetidine/administration & dosage/pharmacology/*therapeutic use
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Immunoglobulins/blood
MH  - Injections, Intravenous
MH  - Male
MH  - Nasal Mucosa/drug effects
MH  - Placebos
MH  - Rhinitis, Allergic, Perennial/*drug therapy
MH  - Time Factors
EDAT- 1993/09/01 00:00
MHDA- 1993/09/01 00:01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 1993/09/01 00:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
AID - 10.1288/00005537-199309000-00012 [doi]
PST - ppublish
SO  - Laryngoscope. 1993 Sep;103(9):1013-9. doi: 10.1288/00005537-199309000-00012.