PMID- 8364454
OWN - NLM
STAT- MEDLINE
DCOM- 19931006
LR  - 20190719
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 16
IP  - 2
DP  - 1993 Feb
TI  - Controlled release of insulin from plasma-irradiated sandwitch device using 
      poly-DL-lactic acid.
PG  - 182-7
AB  - The release behavior of insulin from a plasma-irradiated sandwitch (PIS) device 
      using poly-DL-lactic acid (PLA) was studied. The controlled release device can be 
      obtained by oxygen plasma irradiation (radiofrequency discharge operating at 
      13.56 MHz) on the outer layer of the sandwitch device which was fabricated from 
      an insulin-PLA matrix tablet as a core material and a mixture of 
      plasma-degradable polyoxymethylene (POM) and biodegradable PLA as a wall 
      material. The release test indicated that insulin was released through the 
      micropores formed by the vaporization of POM, and that the release behavior of 
      insulin was affected largely by the molecular weight of PLA used as the outer 
      layer rather than the plasma operational condition. The release of insulin can be 
      controlled by the use of PLA with an average molecular weight of 11000 as the 
      outer layer of the PIS device. Insulin from the PIS device maintained normal 
      blood glucose levels for 10 d in diabetic rats as an implantable dosage form. The 
      duration of insulin effectiveness was relatively short considering the 
      degradation rate of PLA, indicating that the degradation characteristics of 
      biodegradable PLA were not well reflected in the PIS device.
FAU - Yamakawa, I
AU  - Yamakawa I
AD  - Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.
FAU - Watanabe, S
AU  - Watanabe S
FAU - Matsuno, Y
AU  - Matsuno Y
FAU - Kuzuya, M
AU  - Kuzuya M
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Blood Glucose)
RN  - 0 (Buffers)
RN  - 0 (Insulin)
RN  - 0 (Lactates)
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 0 (Resins, Synthetic)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 459TN2L5F5 (poly(lactide))
RN  - 9085-38-5 (delrin)
SB  - IM
MH  - Adsorption
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Buffers
MH  - Diabetes Mellitus, Experimental/blood
MH  - Injections, Subcutaneous
MH  - Insulin/*administration & dosage/pharmacokinetics
MH  - Insulin Infusion Systems
MH  - Lactates/chemistry/pharmacokinetics/*pharmacology
MH  - *Lactic Acid
MH  - Male
MH  - Microscopy, Electron, Scanning
MH  - Molecular Weight
MH  - Polyesters
MH  - Polymers/chemistry/pharmacokinetics/*pharmacology
MH  - Radio Waves
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Resins, Synthetic
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1248/bpb.16.182 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 1993 Feb;16(2):182-7. doi: 10.1248/bpb.16.182.