PMID- 8364686
OWN - NLM
STAT- MEDLINE
DCOM- 19931007
LR  - 20061115
IS  - 1053-6426 (Print)
IS  - 1053-6426 (Linking)
VI  - 2
IP  - 1
DP  - 1993 Feb
TI  - Herring antifreeze protein: primary structure and evidence for a C-type lectin 
      evolutionary origin.
PG  - 20-7
AB  - A complementary DNA (cDNA) for a type II antifreeze protein (AFP) was isolated 
      from an Atlantic herring liver cDNA library and sequenced. The predicted protein 
      sequence is homologous to those of the type II fish AFP from smelt and sea raven; 
      it is also homologous to the carbohydrate recognition domains (CRD) of 
      calcium-dependent (C-type) lectins and similar domains in lectin-like proteins. 
      Herring belong to the infradivision Clupeomorpha, which is distinct from the 
      Euteleostei to which all other AFP-producing fish belong. The occurrence of type 
      II AFP in widely divergent fish groups and their homology to C-type lectin CRDs 
      suggest that type II AFPs evolved from these lectins. Amino acid residues forming 
      the hydrophobic cores of rat mannose-binding protein A (MBP-A) that are conserved 
      in character among C-type lectins are also conserved in the herring AFP. The 
      herring AFP also requires Ca2+ for thermal hysteresis activity. These results 
      suggest that herring AFP is structurally and functionally similar to the CRDs of 
      C-type lectins and related domains in other proteins.
FAU - Ewart, K V
AU  - Ewart KV
AD  - Department of Biology, Memorial University of Newfoundland, St. John's, Canada.
FAU - Fletcher, G L
AU  - Fletcher GL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Mar Biol Biotechnol
JT  - Molecular marine biology and biotechnology
JID - 9205135
RN  - 0 (Antifreeze Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Lectins)
RN  - 0 (Protein Precursors)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antifreeze Proteins
MH  - Base Sequence
MH  - DNA/chemistry/isolation & purification
MH  - Fishes/classification/*genetics
MH  - Freezing
MH  - Gene Library
MH  - Glycoproteins/chemistry/*genetics
MH  - Lectins/chemistry/*genetics
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Protein Precursors/chemistry/*genetics
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
PST - ppublish
SO  - Mol Mar Biol Biotechnol. 1993 Feb;2(1):20-7.