PMID- 8366347
OWN - NLM
STAT- MEDLINE
DCOM- 19931005
LR  - 20191101
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 13
IP  - 9
DP  - 1993 Sep
TI  - Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve 
      growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing 
      rat hippocampus.
PG  - 3818-26
AB  - In previous experiments it has been demonstrated that the synthesis of BDNF 
      (brain-derived neurotrophic factor) and NGF in neurons of the hippocampus is 
      regulated by neuronal activity. The glutamate system is predominantly responsible 
      for upregulation and the GABAergic system for downregulation both in vitro and in 
      vivo (Zafra et al., 1990, 1991). The aim of the present study is to examine the 
      extent to which the cholinergic system is also involved in the regulation of NGF 
      and BDNF mRNA and whether the regulatory contribution of the cholinergic system 
      changes during development. Partial transection of the fimbria fornix bundle in 
      the second postnatal week resulted in a reduction of BDNF and NGF mRNA levels in 
      the hippocampus, suggesting that septal cholinergic input is involved in the 
      regulation of hippocampal BDNF and NGF mRNA levels. Because the fimbria fornix 
      bundle also contains fibers other than cholinergic ones, we further evaluated the 
      importance of the cholinergic influence by injecting pilocarpine, a muscarinic 
      agonist. Pilocarpine markedly increased hippocampal BDNF and NGF mRNA levels in 
      both early postnatal and adult rats. In situ hybridization experiments 
      demonstrated that pilocarpine led to an increase in BDNF expression in the 
      CA1-CA4 regions of the hippocampus and in the dentate gyrus. However, pilocarpine 
      increased NGF mRNA only in those neurons of the dentate gyrus and CA1-CA4 regions 
      that also expressed NGF mRNA in the controls.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - da Penha Berzaghi, M
AU  - da Penha Berzaghi M
AD  - Department of Neurochemistry, Max Planck Institute for Psychiatry, Planegg 
      Martinsried, Germany.
FAU - Cooper, J
AU  - Cooper J
FAU - Castren, E
AU  - Castren E
FAU - Zafra, F
AU  - Zafra F
FAU - Sofroniew, M
AU  - Sofroniew M
FAU - Thoenen, H
AU  - Thoenen H
FAU - Lindholm, D
AU  - Lindholm D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA Probes)
RN  - 0 (RNA, Messenger)
RN  - 01MI4Q9DI3 (Pilocarpine)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - DL48G20X8X (Scopolamine)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Dizocilpine Maleate/pharmacology
MH  - Gene Expression/*drug effects
MH  - Hippocampus/drug effects/growth & development/*metabolism
MH  - In Situ Hybridization
MH  - Injections, Intraventricular
MH  - Kainic Acid/*pharmacology
MH  - Male
MH  - N-Methylaspartate/administration & dosage/pharmacology
MH  - Nerve Growth Factors/*biosynthesis
MH  - Nerve Tissue Proteins/*biosynthesis
MH  - Neurons/drug effects/*metabolism/physiology
MH  - Neurotrophin 3
MH  - Pilocarpine/*pharmacology
MH  - Pyramidal Tracts/drug effects/growth & development/metabolism
MH  - RNA Probes
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Scopolamine/pharmacology
MH  - Transcription, Genetic/drug effects
PMC - PMC6576436
EDAT- 1993/09/01 00:00
MHDA- 1993/09/01 00:01
PMCR- 1994/03/01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 1993/09/01 00:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
PHST- 1994/03/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.13-09-03818.1993 [doi]
PST - ppublish
SO  - J Neurosci. 1993 Sep;13(9):3818-26. doi: 10.1523/JNEUROSCI.13-09-03818.1993.