PMID- 8368888 OWN - NLM STAT- MEDLINE DCOM- 19931007 LR - 20161123 IS - 0772-4128 (Print) IS - 0772-4128 (Linking) VI - 73 IP - 2 DP - 1993 Jun TI - [Factors affecting the efficacy of 2 growth regulator compounds, OMS 3010 (phenoxycarb) and OMS 3019 (ethoxypyridine), on larvae of the Simulium damnosum complex]. PG - 119-25 AB - Two insect growth regulators (IGR'S) acting as juvenile hormone analogs (JHA'S), OMS 3010 (phenoxycarb) and OMS 3019 (ethoxypyridine) were selected after a screening of several compounds proposed by industry on black fly larvae of the Simulium damnosum complex (Diptera: Simuliidae) the vector of onchocerciasis in West Africa. Bioassays were designed to study two parameters: larval age and exposure time. The results showed that these compounds are more efficient on old larvae (6th and 7th instars) than young larvae (3rd, 4th and 5th instars). However, exposure time seems essential. The black fly larvae live in fast running water courses. Thus, it is difficult to insure a prolonged exposure time in natural conditions. Though being active on black fly larvae, three factors are limiting the prospects for operational use of these two compounds: high dosages, limited effectiveness on young instar larvae and exposure time. FAU - Doannio, J M AU - Doannio JM AD - O.C.C.G.E., Institut Pierre Richet, Bouake, Cote d'Ivoire. FAU - Dossou-Yovo, J AU - Dossou-Yovo J FAU - Duval, J AU - Duval J FAU - Hougard, J M AU - Hougard JM FAU - Guillet, P AU - Guillet P LA - fre PT - Journal Article TT - Etude de facteurs conditionnant l'efficacite de deux composes regulateurs de croissance, OMS 3010 (phenoxycarb) et OMS 3019 (ethoxypiridine), sur les larves du complexe Simulium damnosum (Diptera: Simuliidae). PL - Belgium TA - Ann Soc Belg Med Trop JT - Annales de la Societe belge de medecine tropicale JID - 7511864 RN - 0 (Carbamates) RN - 0 (Insecticides) RN - 0 (Juvenile Hormones) RN - 0 (Phenylcarbamates) RN - 0 (Pyridines) RN - 3Q9VOR705O (pyriproxyfen) RN - JEN0LSV1G9 (fenoxycarb) SB - IM MH - Animals MH - Carbamates/*pharmacology MH - Insecticides/*pharmacology MH - Juvenile Hormones/*pharmacology MH - Larva/drug effects MH - *Phenylcarbamates MH - Pyridines/*pharmacology MH - Simuliidae/*drug effects MH - Time Factors EDAT- 1993/06/01 00:00 MHDA- 1993/06/01 00:01 CRDT- 1993/06/01 00:00 PHST- 1993/06/01 00:00 [pubmed] PHST- 1993/06/01 00:01 [medline] PHST- 1993/06/01 00:00 [entrez] PST - ppublish SO - Ann Soc Belg Med Trop. 1993 Jun;73(2):119-25.