PMID- 8370441
OWN - NLM
STAT- MEDLINE
DCOM- 19931008
LR  - 20130523
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 6
IP  - 7
DP  - 1993 Jul
TI  - Pulmonary involvement in human T-cell lymphotropic virus type-I uveitis: 
      T-lymphocytosis and high proviral DNA load in bronchoalveolar lavage fluid.
PG  - 938-43
AB  - The ocular manifestation of human T-cell lymphotropic virus type I (HTLV-I) 
      infection has been recognized as a new clinical entity termed HTLV-I uveitis. In 
      order to determine whether HTLV-I uveitis is associated with lymphocyte 
      alveolitis, bronchoalveolar lavage (BAL) was carried out in 11 patients with 
      HTLV-I uveitis, five asymptomatic HTLV-I carriers, 11 HTLV-I-negative patients 
      with ocular sarcoidosis, and nine normal control subjects seronegative for 
      HTLV-I. Six of the 11 patients with HTLV-I uveitis showed increased total cell 
      counts, and T-lymphocytosis in BAL fluid. CD4+/CD8+ ratios of T-lymphocytes were 
      decreased in three of these patients, and normal in three other patients. Such 
      abnormalities of the lung were not found in asymptomatic HTLV-I carriers, and in 
      normal control subjects. BAL findings in HTLV-I uveitis differed from those of 
      patients with sarcoidosis in terms of the lymphocytic component. Interestingly, 
      it was found that there was an increase of HTLV-I proviral deoxyribonucleic acid 
      (DNA) load in peripheral blood mononuclear cells (PBMC) from seven patients with 
      HTLV-I uveitis, and in the BAL cells from four patients with pulmonary 
      involvement. These results provide further evidence in terms of HTLV-I tropism 
      for the lung, and suggest that a systemic and local increase of HTLV-I proviral 
      DNA load plays an important role in the pathogenesis of lymphocyte alveolitis in 
      patients with HTLV-I uveitis.
FAU - Sugimoto, M
AU  - Sugimoto M
AD  - First Department of Internal Medicine, Kumamoto University School of Medicine, 
      Japan.
FAU - Mita, S
AU  - Mita S
FAU - Tokunaga, M
AU  - Tokunaga M
FAU - Yamaguchi, K
AU  - Yamaguchi K
FAU - Cho, I
AU  - Cho I
FAU - Matsumoto, M
AU  - Matsumoto M
FAU - Mochizuki, M
AU  - Mochizuki M
FAU - Araki, S
AU  - Araki S
FAU - Takatsuki, K
AU  - Takatsuki K
FAU - Ando, M
AU  - Ando M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (DNA, Viral)
SB  - IM
CIN - Eur Respir J. 1993 Jul;6(7):925-9. PMID: 8396535
MH  - Bronchoalveolar Lavage Fluid/*microbiology/pathology
MH  - DNA, Viral/*analysis
MH  - Female
MH  - HTLV-I Infections/*diagnosis
MH  - Human T-lymphotropic virus 1/genetics/*isolation & purification
MH  - Humans
MH  - Lung Diseases/*microbiology
MH  - Lymphocytosis/*microbiology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - T-Lymphocytes/*pathology
MH  - Uveitis/*microbiology
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J. 1993 Jul;6(7):938-43.