PMID- 8371029
OWN - NLM
STAT- MEDLINE
DCOM- 19931014
LR  - 20081121
IS  - 0148-916X (Print)
IS  - 0148-916X (Linking)
VI  - 61
IP  - 2
DP  - 1993 Jun
TI  - Development of giant reaction in response to PPD skin test in lepromatous leprosy 
      patients.
PG  - 205-13
AB  - The present study analyzes some clinical and immunological aspects of the giant 
      reaction (GR) in lepromatous leprosy. Sixteen out of a total of 147 (10.9%) 
      lepromatous patients developed the clinical features of GR upon the intradermal 
      administration of PPD; most (14 of 16) GRs occurred in bacteriologically positive 
      cases. GR precipitated an episode of erythema nodosum leprosum (ENL) in three 
      patients. In addition, patients with GR showed enhanced in vitro response to PPD, 
      by the lymphoproliferation test and interferon-gamma assay, as compared to either 
      PPD-negative individuals or PPD-positive patients without GR. Therefore, 
      cell-mediated-immune response to mycobacterial antigens is present in lepromatous 
      patients with GR. It is suggested that the exacerbated in vivo response to PPD in 
      lepromatous leprosy is the result of an increased immunoreactivity to the 
      antigen, which well may be associated with the local and/or systemic release of 
      cytokines [tumor necrosis factor-alpha (TNF alpha) and interferon-gamma (IFN 
      gamma)] by the inflammatory cells. These episodes may, in fact, play an important 
      role in determining the development of disabilities and reactional states, 
      thereby interfering with the prognosis of leprosy disease.
FAU - Sampaio, E P
AU  - Sampaio EP
AD  - Leprosy Unit, Oswaldo Cruz Foundation, Manguinhos, Rio de Janeiro, Brazil.
FAU - Duppre, N C
AU  - Duppre NC
FAU - Nery, J A
AU  - Nery JA
FAU - Moreira, A L
AU  - Moreira AL
FAU - Sarno, E N
AU  - Sarno EN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Lepr Other Mycobact Dis
JT  - International journal of leprosy and other mycobacterial diseases : official 
      organ of the International Leprosy Association
JID - 8505819
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Tuberculin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antigens, Bacterial/immunology
MH  - Cells, Cultured
MH  - Drug Eruptions/*etiology
MH  - Erythema/*etiology/immunology
MH  - Female
MH  - Humans
MH  - Interferon-gamma/immunology
MH  - Leprosy, Lepromatous/*immunology
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - Monocytes/immunology
MH  - Mycobacterium leprae/immunology
MH  - Tuberculin/*adverse effects
MH  - Tuberculin Test
MH  - Tuberculosis/*diagnosis/immunology
MH  - Tumor Necrosis Factor-alpha/immunology
EDAT- 1993/06/01 00:00
MHDA- 1993/06/01 00:01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 1993/06/01 00:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
PST - ppublish
SO  - Int J Lepr Other Mycobact Dis. 1993 Jun;61(2):205-13.