PMID- 8372432
OWN - NLM
STAT- MEDLINE
DCOM- 19931014
LR  - 20081121
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 196
IP  - 2
DP  - 1993 Oct
TI  - Interfamilial and intrafamilial genomic diversity and molecular phylogeny of 
      human T-cell lymphotropic virus type I from Papua New Guinea and the Solomon 
      Islands.
PG  - 506-13
AB  - To determine the interstrain genomic diversity and molecular phylogeny of the 
      recently identified variants of human T-cell lymphotropic virus type I (HTLV-I) 
      in Melanesia, we enzymatically amplified, then directly sequenced representative 
      regions of the gag, pol, and env genes of HTLV-I strains from 10 members of four 
      families, including one family from Papua New Guinea and three families from the 
      Solomon Islands. When aligned and compared to a Japanese strain of HTLV-I (ATK), 
      the Melanesian HTLV-I strains differed by 7.6 to 8.7% in the gag, 7.1 to 9.3% in 
      the pol, and 7.3 to 8.2% in the env gene regions. Based on 931 nucleotides, the 
      overall sequence divergence of the 10 Melanesian HTLV-I strains from HTLV-I ATK 
      was 7.3 to 8.1% (68 to 75 base substitutions). The intrafamilial genetic 
      heterogeneity among these virus strains was nil to 0.2%, while the interfamilial 
      sequence variation between HTLV-I strains from the Solomon Islands and those from 
      Papua New Guinea was 3.4 to 4.2%, and the genetic heterogeneity among virus 
      strains from the three Solomon Islands families was 0.2 to 0.9%. Using the 
      maximum parsimony and neighbor-joining methods, phylogenetic analysis indicated 
      that the HTLV-I strains from Papua New Guinea and the Solomon Islands formed a 
      monophyletic group and that the Melanesian and cosmopolitan strains of HTLV-I 
      have evolved along two major geographically dependent lineages.
FAU - Nerurkar, V R
AU  - Nerurkar VR
AD  - Laboratory of Central Nervous System Studies, National Institute of Neurological 
      Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
FAU - Song, K J
AU  - Song KJ
FAU - Saitou, N
AU  - Saitou N
FAU - Melland, R R
AU  - Melland RR
FAU - Yanagihara, R
AU  - Yanagihara R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
SB  - IM
MH  - Base Sequence
MH  - Family
MH  - Female
MH  - Genes, Viral/*genetics
MH  - Genes, env/genetics
MH  - Genes, gag/genetics
MH  - Genes, pol/genetics
MH  - *Genetic Variation
MH  - *Genome, Viral
MH  - HTLV-I Infections/*epidemiology
MH  - Human T-lymphotropic virus 1/*genetics/isolation & purification
MH  - Humans
MH  - Male
MH  - Melanesia/epidemiology
MH  - Molecular Sequence Data
MH  - Papua New Guinea/epidemiology
MH  - Phylogeny
MH  - Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
AID - S0042-6822(83)71506-0 [pii]
AID - 10.1006/viro.1993.1506 [doi]
PST - ppublish
SO  - Virology. 1993 Oct;196(2):506-13. doi: 10.1006/viro.1993.1506.