PMID- 8372632
OWN - NLM
STAT- MEDLINE
DCOM- 19931008
LR  - 20211203
IS  - 0001-6314 (Print)
IS  - 0001-6314 (Linking)
VI  - 88
IP  - 1
DP  - 1993 Jul
TI  - Clinical and demographic features of HTLV-1 associated myelopathy/tropical 
      spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brazil.
PG  - 59-62
AB  - In Rio de Janeiro (RJ) most cases of paraparesis of obscure origin are associated 
      with the human T-cell lymphotropic virus type I (HTLV-I). Thirty-four consecutive 
      patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) 
      from RJ were evaluated. Most patients came from low socio-economic levels. There 
      was no difference in terms of gender. The main affected racial group was white. A 
      history of sexually transmitted diseases was a major risk factor for HAM/TSP and 
      a positive serology for syphilis was found in 26.5% of the patients. The major 
      clinical findings were of a spastic paraparesis with generalized brisk tendon 
      jerks and bilateral Babinki's sign. Sensation was abnormal in 25 patients (73.5%) 
      and five (14.7%) had a sensory level. Three patients (8.8%) had optic atrophy. 
      The cerebrospinal fluid showed a lymphocytic pleocytosis with a mean total 
      protein content of 0.4 g/litre, and an increased intrathecal IgG synthesis in 
      59.4% of patients. HAM/TSP and multiple sclerosis (MS) occur indigenously in RJ 
      and some HAM/TSP cases can be sometimes confused with MS. Therefore we propose 
      that, in places where MS coexist with HAM/TSP, HTLV-I antibodies should be sought 
      routinely in those MS suspected cases with prominent spastic paraparesis.
FAU - Araujo, A de Q
AU  - Araujo Ade Q
AD  - HTLV-associated Neuropathies Unit, Evandro Chagas Hospital, Fiocruz, Brazil.
FAU - Alfonso, C R
AU  - Alfonso CR
FAU - Schor, D
AU  - Schor D
FAU - Leite, A C
AU  - Leite AC
FAU - de Andrada-Serpa, M J
AU  - de Andrada-Serpa MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (HTLV-I Antibodies)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brazil/epidemiology
MH  - Cerebrospinal Fluid/chemistry/immunology
MH  - Ethnicity
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - HTLV-I Antibodies/isolation & purification
MH  - Humans
MH  - Leukemia-Lymphoma, Adult T-Cell/complications/*diagnosis
MH  - Male
MH  - Neurologic Examination
MH  - Paraparesis, Tropical Spastic/complications/*diagnosis/epidemiology
MH  - Paresthesia/etiology
MH  - Reflex, Babinski
MH  - Risk Factors
MH  - Sex Factors
MH  - Sexual Behavior
MH  - Sexually Transmitted Diseases/blood/complications
MH  - Syphilis/blood
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
AID - 10.1111/j.1600-0404.1993.tb04188.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 1993 Jul;88(1):59-62. doi: 10.1111/j.1600-0404.1993.tb04188.x.