PMID- 8375747
OWN - NLM
STAT- MEDLINE
DCOM- 19931021
LR  - 20051116
IS  - 0390-6078 (Print)
IS  - 0390-6078 (Linking)
VI  - 78
IP  - 3
DP  - 1993 May-Jun
TI  - Activation of human platelets by monoclonal antibodies.
PG  - 172-7
AB  - Some monoclonal antibodies (mAbs) are able to induce platelet activation and/or 
      aggregation in vitro. Such mAbs show specificity to important platelet membrane 
      glycoproteins (GPs), including GPIIb/IIIa, GPIV, and the HLA complex. Different 
      mechanisms are implicated in mAb-mediated platelet activation: mAbs can interact 
      contemporarily with the target antigen by means of their Fab portion, and with 
      the platelet Fc receptor (Fc gamma RII) through their Fc portion. Frequently, 
      cross-linking Fc gamma RII causes receptor oligomerization, which in turn leads 
      to platelet activation. On the other hand, it has been demonstrated that the 
      target antigen may entirely transduce the activation signal. The activation event 
      sometimes results from a conformational shift of the target antigen. 
      Investigation of the mechanisms leading to mAb-mediated platelet activation will 
      presumably increase our knowledge about platelet activation pathways, and will 
      help in the management of patients having serum platelet-aggregating 
      autoantibodies or alloantibodies.
FAU - Perutelli, P
AU  - Perutelli P
AD  - IV Divisione di Ematologia ed Oncologia Pediatrica, Istituto G. Gaslini, Genova, 
      Italy.
FAU - Mori, P G
AU  - Mori PG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Haematologica
JT  - Haematologica
JID - 0417435
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Platelet Membrane Glycoproteins)
RN  - 0 (Receptors, Fc)
SB  - IM
MH  - *Antibodies, Monoclonal/immunology
MH  - Antibody Specificity
MH  - Humans
MH  - Macromolecular Substances
MH  - *Platelet Activation
MH  - Platelet Membrane Glycoproteins/*immunology
MH  - Receptors, Fc/immunology/physiology
RF  - 92
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
PST - ppublish
SO  - Haematologica. 1993 May-Jun;78(3):172-7.