PMID- 8376218
OWN - NLM
STAT- MEDLINE
DCOM- 19931015
LR  - 20190821
IS  - 0378-5955 (Print)
IS  - 0378-5955 (Linking)
VI  - 68
IP  - 1
DP  - 1993 Jun
TI  - Temporal integration and oscillatory responses of the human auditory cortex 
      revealed by evoked magnetic fields to click trains.
PG  - 89-96
AB  - We recorded neuromagnetic evoked responses from the right auditory cortex of 7 
      healthy adults with a 24-channel planar SQUID gradiometer. The stimuli were 
      200-ms click trains presented at rates of 40, 80, 160 and 320 Hz, with 
      interstimulus intervals (ISIs) of 1 and 4 s. The transient N100m response to the 
      train onset depended on the click rate: the peak latency shortened to the same 
      extent as the interval between successive clicks decreased in trains with rates 
      from 40 Hz to 320 Hz. The N100m amplitude increased simultaneously, saturating at 
      rates of 160-320 Hz. The mean N100m latency was slightly longer with the 1-s than 
      with the 4-s ISI for all click rates. The systematic changes of the N100m 
      amplitude and latency according to click rate demonstrate the importance of 
      temporal integration for N100m generation, and imply an integration time of 20-25 
      ms. The 20- and 40-Hz click trains also elicited oscillatory 40-Hz responses 
      80-250 ms after the train onset. The 40-Hz responses were more resistant than 
      N100m to changes of the ISI, and their sources slightly differed from those of 
      N100m. These two responses evidently reflect different aspects of auditory 
      processing.
FAU - Forss, N
AU  - Forss N
AD  - Low Temperature Laboratory, Helsinki University of Technology, Espoo, Finland.
FAU - Makela, J P
AU  - Makela JP
FAU - McEvoy, L
AU  - McEvoy L
FAU - Hari, R
AU  - Hari R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Hear Res
JT  - Hearing research
JID - 7900445
SB  - IM
MH  - Acoustic Stimulation
MH  - Adult
MH  - Auditory Cortex/*physiology
MH  - Auditory Threshold/physiology
MH  - Evoked Potentials, Auditory, Brain Stem/*physiology
MH  - Female
MH  - Humans
MH  - Male
EDAT- 1993/06/01 00:00
MHDA- 1993/06/01 00:01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 1993/06/01 00:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
AID - 0378-5955(93)90067-B [pii]
AID - 10.1016/0378-5955(93)90067-b [doi]
PST - ppublish
SO  - Hear Res. 1993 Jun;68(1):89-96. doi: 10.1016/0378-5955(93)90067-b.