PMID- 8376845
OWN - NLM
STAT- MEDLINE
DCOM- 19931021
LR  - 20220331
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 168
IP  - 4
DP  - 1993 Oct
TI  - Mononuclear cell subpopulations and cytokine levels in human visceral 
      leishmaniasis before and after chemotherapy.
PG  - 986-93
AB  - Serum cytokine levels and mononuclear cell subpopulations in the spleen and 
      peripheral blood of patients with visceral leishmaniasis before and after 
      antimony therapy were analyzed. The percentages of activated 
      monocytes/macrophages, T cells, and possibly B cells; of gamma/delta T cell 
      receptor (TCR)-bearing T cells; of CD4- CD8- alpha/beta TCR-bearing T cells; and 
      serum levels of tumor necrosis factor-alpha (TNF alpha), interferon-gamma 
      (IFN-gamma), and interleukin-6 (IL-6) were high in patients with active visceral 
      leishmaniasis. The proportion of both helper and suppressor CD4+ cells and of 
      cells with NK and cytotoxic T phenotypes were depressed. Successful chemotherapy 
      normalized these parameters with the exception of activated monocytes. Thus, the 
      impaired cell-mediated immunity in human Leishmania donovani infection is 
      primarily due to a decrease in the proportion and possibly the activity of helper 
      CD4+ cells, while suppressor cells do not seem to play a relevant role. TNF 
      alpha, IL-6, and IFN-gamma may prove to be useful markers for monitoring response 
      to therapy.
FAU - Cenini, P
AU  - Cenini P
AD  - Armaure Hansen Research Institute, Addis Ababa, Ethiopia.
FAU - Berhe, N
AU  - Berhe N
FAU - Hailu, A
AU  - Hailu A
FAU - McGinnes, K
AU  - McGinnes K
FAU - Frommel, D
AU  - Frommel D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Protozoan)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antigens, CD/blood
MH  - Antigens, Protozoan/immunology
MH  - B-Lymphocytes/immunology
MH  - CD4 Antigens/blood
MH  - CD8 Antigens/blood
MH  - Cells, Cultured
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Interferon-gamma/blood
MH  - Interleukin-6/blood
MH  - Leishmaniasis, Visceral/*blood/*immunology
MH  - Lymphocyte Subsets/immunology
MH  - Male
MH  - Monocytes/*immunology
MH  - T-Lymphocytes/immunology
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
AID - 10.1093/infdis/168.4.986 [doi]
PST - ppublish
SO  - J Infect Dis. 1993 Oct;168(4):986-93. doi: 10.1093/infdis/168.4.986.