PMID- 8378033
OWN - NLM
STAT- MEDLINE
DCOM- 19931018
LR  - 20180216
IS  - 0030-2414 (Print)
IS  - 0030-2414 (Linking)
VI  - 50
IP  - 5
DP  - 1993 Sep-Oct
TI  - Cytokine production during intraperitoneal chemohyperthermia.
PG  - 371-4
AB  - The aim of the present work is to investigate in vivo cytokine production during 
      chemohyperthermia. 11 patients suffering from gastric adenocarcinoma (n = 6), 
      ovarian adenocarcinoma (n = 4) or malignant mesothelioma (n = 1) were studied. 
      Patients received 60 mg mitomycin or 100 mg cisplatin per square meter during 2 h 
      in 6 liters of a heating solution (temperature 42 degrees C, flow rate 200 ml/min 
      in a closed circuit) after previous surgical resection. Tumor necrosis 
      factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were measured at 0, 30, 45, 60 
      and 90 min, both in the blood stream and in the heating solution circulating 
      intraperitoneally. We observed a slight increase in plasma IL-6 occurring as soon 
      as 30 min, a dramatic rise in IL-6 in the heating solution. TNF-alpha values were 
      only slightly augmented. In addition, the importance of various factors in the 
      induction of IL-6 and TNF-alpha production during chemohyperthermia (temperature, 
      mitomycin C, cisplatin) were studied using a whole blood ex vivo model.
FAU - Coulon, L
AU  - Coulon L
AD  - Department of Immunology, Centre Hospitalier Lyon-Sud, Pierre-Benite, France.
FAU - Bienvenu, J
AU  - Bienvenu J
FAU - Gutowski, M C
AU  - Gutowski MC
FAU - Barbier, Y
AU  - Barbier Y
FAU - Barbier, M
AU  - Barbier M
FAU - Panteix, G
AU  - Panteix G
FAU - Gilly, F N
AU  - Gilly FN
FAU - Carry, P Y
AU  - Carry PY
FAU - Sayag, A
AU  - Sayag A
FAU - Braillon, G
AU  - Braillon G
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Oncology
JT  - Oncology
JID - 0135054
RN  - 0 (Interleukin-6)
RN  - 0 (Mitomycins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Adenocarcinoma/*metabolism/therapy
MH  - Cisplatin/administration & dosage
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - *Hyperthermia, Induced
MH  - Infusions, Parenteral
MH  - Interleukin-6/*biosynthesis
MH  - Male
MH  - Mesothelioma/*metabolism/therapy
MH  - Mitomycins/administration & dosage
MH  - Ovarian Neoplasms/*metabolism/therapy
MH  - Stomach Neoplasms/*metabolism/therapy
MH  - Temperature
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
EDAT- 1993/09/01 00:00
MHDA- 1993/09/01 00:01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 1993/09/01 00:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
AID - 10.1159/000227212 [doi]
PST - ppublish
SO  - Oncology. 1993 Sep-Oct;50(5):371-4. doi: 10.1159/000227212.