PMID- 8378168
OWN - NLM
STAT- MEDLINE
DCOM- 19931019
LR  - 20211203
IS  - 0269-5022 (Print)
IS  - 0269-5022 (Linking)
VI  - 7
IP  - 3
DP  - 1993 Jul
TI  - Concordance of parental race/ethnicity in relation to the risk of sudden infant 
      death syndrome (SIDS).
PG  - 253-62
AB  - It has been reported that parental human leukocyte antigen (HLA) compatibility is 
      associated with certain adverse reproductive outcomes such as multiple 
      spontaneous fetal losses and malformations, particularly among women without a 
      prior livebirth. In order to study the relation between parental HLA 
      compatibility and the risk of SIDS, a population-based case-control study was 
      conducted using 1982-1990 Washington State linked birth and death certificate 
      data. Concordance of parental race/ethnicity combined with prior maternal fetal 
      loss was used as surrogate measures of parental HLA compatibility. The relation 
      was evaluated separately among infants with and without a prior live-born 
      sibling. Among first liveborn infants, those of racially discordant parents were 
      at reduced risk of SIDS compared with those of racially concordant parents 
      (relative risk [RR] = 0.57, 95% confidence interval = 0.34-0.96). Infants of 
      white-minority parents were all at lower risk of SIDS than infants of white-white 
      parents. Infants of racially concordant parents with two or more prior fetal 
      losses were at increased risk of SIDS (RR = 2.44, 1.07-5.56), relative to infants 
      of racially discordant parents. No such associations were observed among infants 
      with prior live-born siblings. In fact, in this latter population, infants of 
      racially concordant parents tended to have a lower risk of SIDS than those of 
      discordant parents. This study suggests that a portion of SIDS cases, 
      particularly among first live-born infants, may be due to parental HLA sharing. 
      However, final determination of the existence of this relationship requires 
      actual HLA typing of parents of both cases and controls.
FAU - Li, D K
AU  - Li DK
AD  - Department of Epidemiology, School of Public Health and Community Medicine, 
      University of Washington, Seattle.
FAU - Daling, J R
AU  - Daling JR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Paediatr Perinat Epidemiol
JT  - Paediatric and perinatal epidemiology
JID - 8709766
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Fetal Death
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Infant, Newborn
MH  - Parents
MH  - *Racial Groups
MH  - Risk Factors
MH  - Sudden Infant Death/*ethnology/etiology
MH  - Washington/epidemiology
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
AID - 10.1111/j.1365-3016.1993.tb00403.x [doi]
PST - ppublish
SO  - Paediatr Perinat Epidemiol. 1993 Jul;7(3):253-62. doi: 
      10.1111/j.1365-3016.1993.tb00403.x.