PMID- 8380368
OWN - NLM
STAT- MEDLINE
DCOM- 19930208
LR  - 20190512
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 91
IP  - 1
DP  - 1993 Jan
TI  - Lymphotropic viruses in 'common variable' immunodeficiency--PCR analysis of 
      lymphocyte DNA for HIV-1 and HHV-6.
PG  - 50-3
AB  - DNA of circulating lymphocytes obtained from 17 patients with 'common variable' 
      immunodeficiency (CVID) was tested for the presence of HIV-1 sequences, using a 
      variety of primers complementary to conserved regions of HIV-1 genomes. None of 
      the patients was positive. The DNA from 12 CVID patients was tested for the 
      presence of human herpesvirus 6 (HHV-6), using appropriate primers for this virus 
      which is known to remain latent following primary infection in the majority of 
      people during childhood. Similar numbers of patients and normal subjects were 
      positive (about 30%), suggesting that CVID patients are not particularly prone to 
      reactivation of this virus. Despite previous anecdotal reports of an unexplained 
      association between HIV-1 and CVID, we conclude that there is no evidence that 
      this virus is implicated in the pathogenesis of CVID. A role for HHV-6 also seems 
      unlikely.
FAU - Sa'Adu, A
AU  - Sa'Adu A
AD  - Immune Deficiency Research Group, Clinical Research Centre, Harrow, Middlesex, 
      UK.
FAU - Thomson, B J
AU  - Thomson BJ
FAU - Bountiff, L
AU  - Bountiff L
FAU - Webster, A D
AU  - Webster AD
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Base Sequence
MH  - Common Variable Immunodeficiency/*microbiology
MH  - DNA, Viral/*analysis
MH  - Female
MH  - HIV-1/*genetics
MH  - Herpesvirus 6, Human/*genetics
MH  - Humans
MH  - Lymphocytes/*microbiology
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
PMC - PMC1554657
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
PMCR- 1994/01/01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
PHST- 1994/01/01 00:00 [pmc-release]
AID - 10.1111/j.1365-2249.1993.tb03352.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 1993 Jan;91(1):50-3. doi: 10.1111/j.1365-2249.1993.tb03352.x.