PMID- 8380620
OWN - NLM
STAT- MEDLINE
DCOM- 19930217
LR  - 20220317
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 103
IP  - 1 Pt 1
DP  - 1993 Jan
TI  - Drug-induced, life-threatening angioedema revisited.
PG  - 10-2
AB  - Few drug reactions are more life threatening than the sudden development of edema 
      involving the mucosal and submucosal layers of the upper aerodigestive tract. 
      Drug-induced angioedema is a recognized entity of angiotensin-converting enzyme 
      (ACE) inhibitors, and despite reports in medical journals and drug insert 
      warnings, captopril and enalapril continue to be widely prescribed. As these 
      drugs are efficacious and usually well-tolerated in the treatment of mild forms 
      of hypertension, their popularity is rising. From June 1, 1984 to August 1, 1991, 
      36 patients with angioedema secondary to ACE inhibitors presented at the Medical 
      College of Virginia Hospitals. Thirty were successfully managed with medical 
      therapy. Two were intubated, 1 had placement of a nasal trumpet, and 3 required 
      tracheostomies. Of extreme importance is the recognition that angioedema 
      resulting from ACE inhibitors is probably not immunoglobulin E (IgE) mediated and 
      that antihistaminics and steroids may not alleviate the airway obstruction. The 
      otolaryngologist must be prepared for the need of possible early surgical 
      intervention.
FAU - Thompson, T
AU  - Thompson T
AD  - Department of Otolarynology--Head and Neck Surgery, Virginia Commonwealth 
      University, Medical College of Virginia, Richmond.
FAU - Frable, M A
AU  - Frable MA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Dipeptides)
RN  - 69PN84IO1A (Enalapril)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 8GTS82S83M (Diphenhydramine)
RN  - 9G64RSX1XD (Captopril)
RN  - E7199S1YWR (Lisinopril)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Airway Obstruction/chemically induced/drug therapy
MH  - Angioedema/*chemically induced/drug therapy
MH  - Angiotensin-Converting Enzyme Inhibitors/*adverse effects
MH  - Captopril/*adverse effects
MH  - Dexamethasone/administration & dosage/therapeutic use
MH  - Dipeptides/*adverse effects
MH  - Diphenhydramine/administration & dosage/therapeutic use
MH  - Enalapril/*adverse effects
MH  - Epinephrine/administration & dosage/therapeutic use
MH  - Female
MH  - Humans
MH  - Injections, Intravenous
MH  - Laryngeal Edema/chemically induced/drug therapy
MH  - Lisinopril
MH  - Male
MH  - Middle Aged
MH  - Mouth Diseases/chemically induced/drug therapy
MH  - Pharyngeal Diseases/chemically induced/drug therapy
MH  - Prognosis
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1288/00005537-199301000-00003 [doi]
PST - ppublish
SO  - Laryngoscope. 1993 Jan;103(1 Pt 1):10-2. doi: 10.1288/00005537-199301000-00003.