PMID- 8380901
OWN - NLM
STAT- MEDLINE
DCOM- 19930225
LR  - 20071114
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 16
IP  - 1
DP  - 1993 Jan
TI  - Peripheral nerve lesions in HTLV-I associated myelopathy (HAM/TSP).
PG  - 21-6
AB  - Peripheral nerve dysfunction (PND) was found in as many as 43% of our patients 
      with human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy 
      (HAM/TSP). To evaluate the PND further we biopsied the sural nerve in 6 patients. 
      The histological features were varying degrees of demyelination, remyelination, 
      axonal atrophy and degeneration, and perineurial fibrosis. "Globule" or "sausage" 
      formation was prominent in two of the specimens. Inflammatory infiltrates were 
      absent. No deposits of IgG, IgM, IgA, or complement were detected in the 
      biopsies. No viral antigen or proviral DNA was detected. It is proposed that the 
      PND and the histological findings noted are part of HTLV-I-associated disease and 
      not an unrelated disorder. The pathogenesis of the PND remains unclear. There was 
      no evidence of direct viral infection. The histological findings could represent 
      primary changes induced by viral-triggered release of soluble factors, such as 
      cytokines or secondary changes to more proximal disease, e.g., root involvement.
FAU - Bhigjee, A I
AU  - Bhigjee AI
AD  - Neurology Unit, University of Natal Medical School, Durban, South Africa.
FAU - Bill, P L
AU  - Bill PL
FAU - Wiley, C A
AU  - Wiley CA
FAU - Windsor, I M
AU  - Windsor IM
FAU - Matthias, D A
AU  - Matthias DA
FAU - Amenomori, T
AU  - Amenomori T
FAU - Wachsman, W
AU  - Wachsman W
FAU - Moorhouse, D
AU  - Moorhouse D
LA  - eng
GR  - NS-24178/NS/NINDS NIH HHS/United States
GR  - NS-278104/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Microscopy, Electron
MH  - Middle Aged
MH  - Neural Conduction/physiology
MH  - Paraparesis, Tropical Spastic/complications/pathology/*physiopathology
MH  - Peripheral Nervous System Diseases/etiology/pathology/*physiopathology
MH  - Reaction Time/physiology
MH  - Sural Nerve/pathology/physiopathology/ultrastructure
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1002/mus.880160106 [doi]
PST - ppublish
SO  - Muscle Nerve. 1993 Jan;16(1):21-6. doi: 10.1002/mus.880160106.