PMID- 8382331
OWN - NLM
STAT- MEDLINE
DCOM- 19930322
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 52
IP  - 9
DP  - 1993
TI  - Differential sensitivity to dexamethasone influence on morphine antinociception 
      in two different strains of mice: DBA/2J and C57BL/6.
PG  - 835-44
AB  - The influence of dexamethasone on morphine antinociception in two different 
      strains of mice (DBA/2J and C57BL/6) was studied by using the hot plate test. 
      Intracerebroventricular (i.c.v.) injection of dexamethasone induced a significant 
      increase of nociceptive response in DBA/2J but not in C57BL/6 mice. 
      Intraperitoneal (i.p.) injection of dexamethasone did not modify nociceptive 
      response both in DBA/2J and C57BL/6 mice. Both i.c.v. and i.p. injection of 
      dexamethasone did not modify morphine antinociception in DBA/2J mice whereas a 
      significant reduction of morphine antinociception was observed in C57BL/6 mice 
      after i.p. injection of dexamethasone. These results suggest that the use of 
      different genetic strains may provide an useful approach for studying 
      dexamethasone-morphine antinociception interaction.
FAU - Capasso, A
AU  - Capasso A
AD  - Department of Experimental Pharmacology, University of Naples, Italy.
FAU - Di Giannuario, A
AU  - Di Giannuario A
FAU - Loizzo, A
AU  - Loizzo A
FAU - Pieretti, S
AU  - Pieretti S
FAU - Sorrentino, L
AU  - Sorrentino L
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Receptors, Opioid, mu)
RN  - 76I7G6D29C (Morphine)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Animals
MH  - Dexamethasone/administration & dosage/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Morphine/*antagonists & inhibitors
MH  - Pain Measurement/*drug effects
MH  - Receptors, Opioid, mu/drug effects
MH  - Species Specificity
MH  - Time Factors
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 0024-3205(93)90082-E [pii]
AID - 10.1016/0024-3205(93)90082-e [doi]
PST - ppublish
SO  - Life Sci. 1993;52(9):835-44. doi: 10.1016/0024-3205(93)90082-e.