PMID- 8383094
OWN - NLM
STAT- MEDLINE
DCOM- 19930405
LR  - 20190722
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 90
IP  - 6
DP  - 1993 Feb
TI  - Identification of an alternative 5' untranslated region of the adenomatous 
      polyposis coli gene.
PG  - 650-2
AB  - cDNA clones, representing transcripts expressed in human fetal brain, have been 
      isolated that specify the 5' end of the adenomatous polyposis coli (APC) gene. 
      Sequence analyses have revealed an alternative 5' untranslated region (5'UTR) of 
      the APC gene; this region is comprised of at least 103 basepairs. A comparison of 
      this alternative UTR with the published sequence of the APC-gene indicates that 
      these two 5'UTR sequences diverge beyond nucleotide position -20 with respect to 
      the A of the authentic translational initiation codon. These data suggest that 
      two APC-specific promoter elements exist, giving rise to two different 
      untranslated regions. Within the alternative UTR, we have identified 3 additional 
      AUG codons, located 5' to the intrinsic APC initiation site. Two of these AUG 
      codons are located in a nucleotide context that favours initiation of truncated 
      translation products. The relevance of these additional AUG codons to a 
      regulatory mechanism acting at the post-transcriptional level of APC gene 
      expression is discussed.
FAU - Lambertz, S
AU  - Lambertz S
AD  - Institut fur Humangenetik der Universitat, Erlangen, Germany.
FAU - Ballhausen, W G
AU  - Ballhausen WG
LA  - eng
SI  - GENBANK/L13238
SI  - GENBANK/L13296
SI  - GENBANK/L13297
SI  - GENBANK/L14001
SI  - GENBANK/L14002
SI  - GENBANK/L14003
SI  - GENBANK/S56365
SI  - GENBANK/S70572
SI  - GENBANK/S70573
SI  - GENBANK/X66424
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
RN  - 0 (Codon)
SB  - IM
GS  - APC
MH  - Adenomatous Polyposis Coli/*genetics
MH  - Codon
MH  - Exons
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - Promoter Regions, Genetic
MH  - *Protein Biosynthesis
MH  - *Proto-Oncogenes
MH  - *RNA Processing, Post-Transcriptional
MH  - Sequence Analysis, DNA
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1007/BF00202484 [doi]
PST - ppublish
SO  - Hum Genet. 1993 Feb;90(6):650-2. doi: 10.1007/BF00202484.