PMID- 8383182
OWN - NLM
STAT- MEDLINE
DCOM- 19930402
LR  - 20061115
IS  - 0022-1317 (Print)
IS  - 0022-1317 (Linking)
VI  - 74 ( Pt 3)
DP  - 1993 Mar
TI  - The glycoprotein B homologue of human herpesvirus 6.
PG  - 495-500
AB  - The gene for the homologue of herpesvirus glycoprotein B (gB) has been identified 
      in the genome of human herpesvirus 6 (HHV-6), strain U1102, and the nucleotide 
      sequence was determined. The open reading frame encodes a protein of 830 amino 
      acids (93.2K) with the characteristics of a transmembrane glycoprotein and close 
      similarity to the gp58/116 complex of human cytomegalovirus (HCMV). Monoclonal 
      antibodies 2D10 and 2B9 have been shown previously to react with an HHV-6 
      glycoprotein of apparent M(r) 112K, and its proteolytic cleavage products of M(r) 
      64K and 58K. We show that both monoclonal antibodies detect prokaryotically 
      expressed carboxy-terminal fragments of the HHV-6 gB homologue. This indicates 
      that the HHV-6 gB homologue is probably processed by proteolytic cleavage similar 
      to its equivalents in HCMV and various other herpesviruses.
FAU - Ellinger, K
AU  - Ellinger K
AD  - Institut fur klinische und molekulare Virologie, Universitat Erlangen-Nurnberg, 
      Germany.
FAU - Neipel, F
AU  - Neipel F
FAU - Foa-Tomasi, L
AU  - Foa-Tomasi L
FAU - Campadelli-Fiume, G
AU  - Campadelli-Fiume G
FAU - Fleckenstein, B
AU  - Fleckenstein B
LA  - eng
SI  - GENBANK/Z18287
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Viral Envelope Proteins)
RN  - 148770-71-2 (glycoprotein B, human herpesvirus-6)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antibodies, Monoclonal
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Herpesvirus 6, Human/*genetics
MH  - Molecular Sequence Data
MH  - Open Reading Frames/genetics
MH  - Protein Processing, Post-Translational/physiology
MH  - Viral Envelope Proteins/*genetics/metabolism
EDAT- 1993/03/01 00:00
MHDA- 1993/03/01 00:01
CRDT- 1993/03/01 00:00
PHST- 1993/03/01 00:00 [pubmed]
PHST- 1993/03/01 00:01 [medline]
PHST- 1993/03/01 00:00 [entrez]
AID - 10.1099/0022-1317-74-3-495 [doi]
PST - ppublish
SO  - J Gen Virol. 1993 Mar;74 ( Pt 3):495-500. doi: 10.1099/0022-1317-74-3-495.