PMID- 8383881
OWN - NLM
STAT- MEDLINE
DCOM- 19930412
LR  - 20140912
IS  - 0256-9574 (Print)
VI  - 83
IP  - 2
DP  - 1993 Feb
TI  - A survey of a small group of workers exposed to toluene di-isocyanate.
PG  - 100-3
AB  - All 20 workers exposed to toluene di-isocyanate (TDI) in a chemical processing 
      and packing factory were tested for TDI-induced asthma. The assessment included a 
      respiratory symptom questionnaire, spirometry, skin prick tests for common 
      allergens and assessment of total and TDI-specific immunoglobulin E (IgE) levels 
      by radio-allergosorbent tests. Six workers had symptoms suggestive of TDI-related 
      asthma. Three of these 6 workers had a significant cross-shift decline in forced 
      expiratory volume in 1 second (FEV1) (10% or greater). Two of the 6 had high 
      levels of TDI-specific IgE. Of the 14 workers without work-related symptoms, 1 
      had a significant cross-shift decline in FEV1. There was no significant 
      association between the levels of exposure to TDI and symptoms, lung function 
      parameters or immunological findings. This study demonstrates the difficulties in 
      correlating immunological status with clinical and lung function findings in 
      workers exposed to TDI. Recommendations include a stepwise approach to diagnosing 
      TDI-induced asthma in exposed workers.
FAU - Soderlund, N
AU  - Soderlund N
AD  - National Centre for Occupational Health, Department of Health and Population 
      Development, Johannesburg.
FAU - Rees, D
AU  - Rees D
FAU - Wasserfall, C
AU  - Wasserfall C
FAU - Roodt, L
AU  - Roodt L
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
RN  - 17X7AFZ1GH (Toluene 2,4-Diisocyanate)
SB  - IM
MH  - Asthma/*chemically induced/diagnosis
MH  - *Chemical Industry
MH  - Humans
MH  - Occupational Exposure/*adverse effects
MH  - Radioallergosorbent Test
MH  - Respiratory Function Tests
MH  - Skin Tests
MH  - Toluene 2,4-Diisocyanate/*adverse effects
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
PST - ppublish
SO  - S Afr Med J. 1993 Feb;83(2):100-3.