PMID- 8384616
OWN - NLM
STAT- MEDLINE
DCOM- 19930427
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 74
IP  - 2
DP  - 1993 Feb
TI  - Blood glutathione status during exercise: effect of carbohydrate supplementation.
PG  - 788-92
AB  - Blood glutathione status and activities of antioxidant enzymes have been 
      investigated during prolonged exercise with or without carbohydrate (CHO) 
      supplementation. Eight subjects cycled at approximately 70% of maximal oxygen 
      uptake to fatigue [134 +/- 19 (SE) min] on the first occasion (control, CON) and 
      at the same work load and duration on the second occasion but with CHO ingestion 
      during exercise. Blood reduced glutathione (GSH) concentration increased from 
      0.55 +/- 0.05 mM at rest to 0.77 +/- 0.09 mM after 120 min of exercise during CON 
      (P < 0.01) but remained constant during CHO exercise. Blood glutathione disulfide 
      (GSSG) levels were unchanged during CON and CHO exercise. Blood GSH + GSSG 
      content and GSH/GSSG ratio were also significantly (P < 0.05) elevated during CON 
      but not during CHO exercise. The increases in GSH and GSH + GSSG in CON were 
      associated with decreases in plasma glucose and insulin levels. Activities of 
      blood GSH peroxidase, GSSG reductase, and glucose-6-phosphate dehydrogenase were 
      significantly increased during the CHO exercise, whereas only GSSG reductase 
      activity was elevated during the CON ride. It is concluded that blood GSH 
      increases during prolonged exercise and that CHO supplementation may prevent 
      blood GSH increase possibly because of its inhibitory effects on hepatic hormonal 
      releases, which stimulate GSH output.
FAU - Ji, L L
AU  - Ji LL
AD  - Department of Kinesiology, University of Illinois, Urbana 61801.
FAU - Katz, A
AU  - Katz A
FAU - Fu, R
AU  - Fu R
FAU - Griffiths, M
AU  - Griffiths M
FAU - Spencer, M
AU  - Spencer M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Hemoglobins)
RN  - 0 (Insulin)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Adult
MH  - Anaerobiosis
MH  - Bicycling
MH  - Cyclic AMP/biosynthesis
MH  - *Diet
MH  - Dietary Carbohydrates/*pharmacology
MH  - Exercise/*physiology
MH  - Female
MH  - Glucosephosphate Dehydrogenase/metabolism
MH  - Glutathione/*blood
MH  - Glutathione Peroxidase/blood
MH  - Glutathione Reductase/metabolism
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Liver/metabolism
MH  - Male
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - Oxygen Consumption
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
AID - 10.1152/jappl.1993.74.2.788 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1993 Feb;74(2):788-92. doi: 10.1152/jappl.1993.74.2.788.