PMID- 8388303
OWN - NLM
STAT- MEDLINE
DCOM- 19930621
LR  - 20190512
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 109
IP  - 1
DP  - 1993 May
TI  - L-arginine exerts a dual role in nociceptive processing in the brain: involvement 
      of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway.
PG  - 73-9
AB  - 1. Intracerebroventricular (i.c.v.) administration of L-arginine (L-Arg), at 
      10-100 micrograms per mouse, produced antinociception in mice, as assessed by the 
      tail flick test; this antinociception was reversed by pretreatment (s.c.) with 
      naltrindole (NTI), a delta-selective opioid antagonist, and by co-administered 
      L-leucyl-L-arginine (Leu-Arg), a kyotorphin (endogenous Met-enkephalin releaser) 
      receptor antagonist. 2. L-NG-nitroarginine methyl ester (L-NAME), a NO synthase 
      inhibitor, but not D-NG-nitroarginine methyl ester, given i.c.v. at 3-10 
      micrograms per mouse, exhibited antinociceptive activity that was resistant to 
      naloxone (s.c.), NTI (s.c.) and Leu-Arg (i.c.v.). 3. The L-NAME (i.c.v.)-induced 
      antinociception was not reversed by L-Arg (i.c.v.), which was antinociceptive by 
      itself, but was abolished by combined injection of L-Arg plus Leu-Arg (i.c.v.) or 
      by L-Arg (i.c.v.) after NTI (s.c.). 4. Methylene blue (MB), a soluble guanylate 
      cyclase inhibitor, at 0.1-1 microgram per mouse, produced antinociception by 
      i.c.v. administration. The antinociception induced by MB (i.c.v.) or L-NAME 
      (i.c.v.) was reversed by co-administered dibutyryl cyclic GMP. 5. These findings 
      suggest that L-Arg plays a dual role in nociceptive processing in the brain, 
      being antinociceptive via the kyotorphin-Met-enkephalin pathway and nociceptive 
      via the NO-cyclic GMP pathway.
FAU - Kawabata, A
AU  - Kawabata A
AD  - Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kinki University, 
      Higashi-Osaka, Japan.
FAU - Umeda, N
AU  - Umeda N
FAU - Takagi, H
AU  - Takagi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Analgesics)
RN  - 0 (Endorphins)
RN  - 0 (Narcotic Antagonists)
RN  - 02N30CW3X0 (kyotorphin)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 36B82AMQ7N (Naloxone)
RN  - 58569-55-4 (Enkephalin, Methionine)
RN  - 5S6W795CQM (Naltrexone)
RN  - 94ZLA3W45F (Arginine)
RN  - G167Z38QA4 (naltrindole)
RN  - H2D2X058MU (Cyclic GMP)
RN  - T42P99266K (Methylene Blue)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Analgesics/*pharmacology
MH  - Animals
MH  - Arginine/administration & dosage/analogs & derivatives/antagonists & 
      inhibitors/*pharmacology
MH  - Brain/*drug effects
MH  - Cyclic GMP/*pharmacology
MH  - Endorphins/*pharmacology
MH  - Enkephalin, Methionine/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Methylene Blue/administration & dosage/pharmacology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - NG-Nitroarginine Methyl Ester
MH  - Naloxone/pharmacology
MH  - Naltrexone/analogs & derivatives/pharmacology
MH  - Narcotic Antagonists/pharmacology
MH  - Neural Pathways/drug effects
MH  - Nitric Oxide/*pharmacology
MH  - Nociceptors/*drug effects/physiology
MH  - Pain Measurement/drug effects
MH  - Spinal Cord/drug effects
PMC - PMC2175590
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
PMCR- 1994/05/01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
PHST- 1994/05/01 00:00 [pmc-release]
AID - 10.1111/j.1476-5381.1993.tb13533.x [doi]
PST - ppublish
SO  - Br J Pharmacol. 1993 May;109(1):73-9. doi: 10.1111/j.1476-5381.1993.tb13533.x.