PMID- 8388358
OWN - NLM
STAT- MEDLINE
DCOM- 19930621
LR  - 20180216
IS  - 0301-0147 (Print)
IS  - 0301-0147 (Linking)
VI  - 23 Suppl 1
DP  - 1993 Mar
TI  - Antithrombotic activity and its relationship to in vitro anticoagulant effects.
PG  - 99-102
AB  - Antithrombotic activities of low molecular weight heparins (LMWHs) in a venous 
      stasis thrombosis model, when compared to unfractionated heparin (UFH), 
      correlated better with anti-IIa activities and inhibition of thrombin generation 
      than with anti-Xa activities. The relative antithrombotic potencies of LMWHs were 
      closer to inhibitory activity in thrombin generation with platelet-poor plasma 
      than platelet-rich plasma. Comparing activities in intrinsic and extrinsic 
      systems, higher concentrations of heparins were required in vitro to inhibit 
      intrinsic thrombin generation than extrinsic thrombin production; however, higher 
      doses were required to prevent in vivo thrombotic events initiated via the 
      extrinsic pathway.
FAU - Gray, E
AU  - Gray E
AD  - National Institute for Biological Standards and Control, Potters Bar, Herts, UK.
FAU - Padilla, A
AU  - Padilla A
FAU - Barrowcliffe, T W
AU  - Barrowcliffe TW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Haemostasis
JT  - Haemostasis
JID - 0371574
RN  - 0 (Anticoagulants)
RN  - 0 (Factor Xa Inhibitors)
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9001-26-7 (Prothrombin)
RN  - 9002-04-4 (Factor IIa)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.21.5 (Thrombin)
SB  - IM
MH  - Animals
MH  - Anticoagulants/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Factor Xa Inhibitors
MH  - Fibrinolytic Agents/*pharmacology
MH  - Heparin/pharmacology/therapeutic use
MH  - Heparin, Low-Molecular-Weight/*pharmacology/therapeutic use
MH  - Prothrombin/antagonists & inhibitors
MH  - Rabbits
MH  - Thrombin/biosynthesis
MH  - Thrombophlebitis/prevention & control
EDAT- 1993/03/01 00:00
MHDA- 1993/03/01 00:01
CRDT- 1993/03/01 00:00
PHST- 1993/03/01 00:00 [pubmed]
PHST- 1993/03/01 00:01 [medline]
PHST- 1993/03/01 00:00 [entrez]
AID - 10.1159/000216916 [doi]
PST - ppublish
SO  - Haemostasis. 1993 Mar;23 Suppl 1:99-102. doi: 10.1159/000216916.