PMID- 8390628
OWN - NLM
STAT- MEDLINE
DCOM- 19930719
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 152
IP  - 1-2
DP  - 1993 Apr 2
TI  - Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and 
      low-affinity nerve growth factor receptor (LNGFR) mRNA levels in cultured rat 
      Schwann cells; differential time- and dose-dependent regulation by cAMP.
PG  - 37-40
AB  - Steady-state mRNA levels for NGF, BDNF, and NT-3, and their receptors, LNGFR, 
      trk, trkB, and trkC, were examined in cultured rat Schwann cells. NGF, BDNF, and 
      LNGFR mRNAs were expressed in control Schwann cells, but NT-3, trk, trkB and trkC 
      mRNAs were not. As previously reported, when Schwann cells were treated with 
      forskolin or 8-bromo-cAMP, NGF mRNA expression was enhanced, while BDNF and LNGFR 
      mRNA levels were suppressed. The optimal concentration of forskolin for NGF mRNA 
      enhancement and BDNF mRNA suppression was similar to that for LNGFR mRNA 
      suppression, which coincided with the optimal concentration for Schwann cells to 
      differentiate. However, the lag-time for forskolin-induces down-regulation of 
      LNGFR mRNA was far greater than that for NGF mRNA increase and BDNF mRNA 
      suppression.
FAU - Yamamoto, M
AU  - Yamamoto M
AD  - Fourth Department of Internal Medicine, Aichi Medical University, Japan.
FAU - Sobue, G
AU  - Sobue G
FAU - Li, M
AU  - Li M
FAU - Arakawa, Y
AU  - Arakawa Y
FAU - Mitsuma, T
AU  - Mitsuma T
FAU - Kimata, K
AU  - Kimata K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Receptors, Neurotransmitter)
RN  - 0 (Receptors, Tachykinin)
RN  - 1F7A44V6OU (Colforsin)
RN  - 23583-48-4 (8-Bromo Cyclic Adenosine Monophosphate)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 2.7.10.1 (Receptor, trkA)
SB  - IM
MH  - 8-Bromo Cyclic Adenosine Monophosphate/pharmacology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Cells, Cultured
MH  - Colforsin/pharmacology
MH  - Cyclic AMP/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Regulation/*drug effects
MH  - Nerve Growth Factors/biosynthesis/*genetics
MH  - Nerve Tissue Proteins/biosynthesis/*genetics
MH  - Proto-Oncogene Proteins/biosynthesis/*genetics
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkA
MH  - Receptors, Nerve Growth Factor/biosynthesis/*genetics
MH  - Receptors, Neurotransmitter/biosynthesis/*genetics
MH  - Receptors, Tachykinin
MH  - Schwann Cells/*metabolism
MH  - Second Messenger Systems/*drug effects
EDAT- 1993/04/02 00:00
MHDA- 1993/04/02 00:01
CRDT- 1993/04/02 00:00
PHST- 1993/04/02 00:00 [pubmed]
PHST- 1993/04/02 00:01 [medline]
PHST- 1993/04/02 00:00 [entrez]
AID - 0304-3940(93)90477-3 [pii]
AID - 10.1016/0304-3940(93)90477-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 1993 Apr 2;152(1-2):37-40. doi: 10.1016/0304-3940(93)90477-3.