PMID- 8391126
OWN - NLM
STAT- MEDLINE
DCOM- 19930723
LR  - 20131121
IS  - 0888-8809 (Print)
IS  - 0888-8809 (Linking)
VI  - 7
IP  - 5
DP  - 1993 May
TI  - The mouse retinoid-X receptor-gamma gene: genomic organization and evidence for 
      functional isoforms.
PG  - 651-8
AB  - Retinoid-X receptors (RXRs) are a subfamily of the steroid/thyroid nuclear 
      receptor superfamily. There are three RXR genes: alpha, beta, and gamma, each 
      with a distinct expression pattern and chromosomal location. In this study we 
      describe the genomic organization of the mouse RXR gamma gene, identify a second 
      mouse (m) RXR gamma isoform, and map the exons of the two mRXR gamma isoforms on 
      the gene. The new mRXR gamma isoform, called gamma 2, has a unique 
      5'-untranslated region, and is expressed highly in both cardiac and skeletal 
      muscles, but very little in the liver, while the mRXR gamma 1 is expressed in the 
      brain and muscle. The gamma 2 isoform is also a functional receptor and can 
      transactivate the retinoid response elements of the apolipoprotein-AI and 
      cellular retinol-binding protein-II genes. The mRXR gamma gene spans at least 50 
      kilobases of DNA on mouse chromosome 1 and has nine introns ranging from 107 
      basepairs to more than 30 kilobases. From the genomic separation of the two 
      unique 5'-ends of the mRXR gamma isoforms, it is suggested that this gene may 
      have two promoters, similar to those described for the three RAR genes. The 
      results of this study along with those of previously published studies suggest 
      that there may be more than two isoforms of mRXR gamma.
FAU - Liu, Q
AU  - Liu Q
AD  - Department of Microbiology, Duke University Medical Center, Durham, North 
      Carolina 27710.
FAU - Linney, E
AU  - Linney E
LA  - eng
GR  - CA-39066/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Endocrinol
JT  - Molecular endocrinology (Baltimore, Md.)
JID - 8801431
RN  - 0 (Carrier Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 5688UTC01R (Tretinoin)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Carrier Proteins/genetics
MH  - DNA/chemistry
MH  - Exons
MH  - Gene Expression/drug effects
MH  - Introns
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Receptors, Cell Surface/chemistry/*genetics
MH  - Receptors, Retinoic Acid
MH  - Receptors, Thyroid Hormone/genetics
MH  - Restriction Mapping
MH  - Retinoid X Receptors
MH  - *Transcription Factors
MH  - Tretinoin/pharmacology
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
AID - 10.1210/mend.7.5.8391126 [doi]
PST - ppublish
SO  - Mol Endocrinol. 1993 May;7(5):651-8. doi: 10.1210/mend.7.5.8391126.