PMID- 8392190
OWN - NLM
STAT- MEDLINE
DCOM- 19930806
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 90
IP  - 13
DP  - 1993 Jul 1
TI  - 9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for 
      retinoid X receptor involvement in thymocyte development.
PG  - 6170-4
AB  - Retinoic acid is a morphogenetic signaling molecule derived from vitamin A and 
      involved in vertebrate development. Two groups of receptors, retinoic acid 
      receptors and retinoid X receptors (RXRs), have been identified. 
      All-trans-retinoic acid is the high-affinity ligand for retinoic acid receptors, 
      and 9-cis-retinoic acid additionally binds RXRs with high affinity. Here we 
      report that although retinoic acid has little inhibitory effect on 
      activation-induced T-cell proliferation, it specifically prevents 
      activation-induced apoptosis of T-cell hybridomas and antigen-specific deletion 
      of immature CD4+CD8+ thymocytes from alpha beta T-cell receptor transgenic mice. 
      9-cis-Retinoic acid was approximately 10-fold more potent than all-trans-retinoic 
      acid, suggesting that RXRs participate in this process. Thus, although 
      9-cis-retinoic acid has little immuno-suppressive activity, it is a potent 
      negative regulator of activation-induced T-cell apoptosis, raising the 
      possibility that RXRs may take part in regulating T-cell development.
FAU - Yang, Y
AU  - Yang Y
AD  - Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes 
      of Health, Bethesda, MD 20892.
FAU - Vacchio, M S
AU  - Vacchio MS
FAU - Ashwell, J D
AU  - Ashwell JD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Cells, Cultured
MH  - Female
MH  - Hybridomas
MH  - *Lymphocyte Activation
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Receptors, Antigen, T-Cell/physiology
MH  - Receptors, Cell Surface/*physiology
MH  - *Receptors, Retinoic Acid
MH  - Retinoid X Receptors
MH  - T-Lymphocytes/*drug effects/physiology
MH  - *Transcription Factors
MH  - Tretinoin/*pharmacology
PMC - PMC46889
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
PMCR- 1994/01/01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
PHST- 1994/01/01 00:00 [pmc-release]
AID - 10.1073/pnas.90.13.6170 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6170-4. doi: 10.1073/pnas.90.13.6170.