PMID- 8392894
OWN - NLM
STAT- MEDLINE
DCOM- 19930826
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 611
IP  - 2
DP  - 1993 May 21
TI  - Involvement of spinal kappa opioid receptors in a type of footshock induced 
      analgesia in mice.
PG  - 264-71
AB  - We have studied the effects of several opioid antagonists on a type of footshock 
      stress-induced analgesia (FSIA) measured by the tail-flick test in male mice. 
      Naloxone injected either subcutaneously (0.1-10 mg/kg) or intrathecally (1-20 
      micrograms) antagonized FSIA at higher doses than those that blocked a similar 
      degree of analgesia induced by morphine. Intracerebroventricular (i.c.v.) 
      naloxone (1-20 micrograms) did not modify the FSIA while antagonizing the i.c.v. 
      morphine-induced analgesia. As a consequence, the antagonism of the FSIA by 
      naloxone probably occurs at the level of the spinal cord and through receptors 
      different than mu. The delta selective antagonist naltrindole (0.1-3 mg/kg s.c.) 
      did not antagonize the analgesic effects of the stress. Nor-binaltorphimine, a 
      kappa selective antagonist, blocked the FSIA when administered systemically (1-4 
      mg/kg i.p.) or locally (0.1-1 microgram i.t.). These results strongly suggest 
      that spinal kappa opioid receptors are responsible for this type of endogenous 
      analgesia.
FAU - Menendez, L
AU  - Menendez L
AD  - Departamento de Medicina, Facultad de Medicina, Universidad de Oviedo, Spain.
FAU - Andres-Trelles, F
AU  - Andres-Trelles F
FAU - Hidalgo, A
AU  - Hidalgo A
FAU - Baamonde, A
AU  - Baamonde A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Receptors, Opioid, kappa)
RN  - 36B82AMQ7N (Naloxone)
RN  - 36OOQ86QM1 (norbinaltorphimine)
RN  - 5S6W795CQM (Naltrexone)
RN  - 76I7G6D29C (Morphine)
RN  - G167Z38QA4 (naltrindole)
SB  - IM
MH  - *Analgesia
MH  - Animals
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - *Electroshock
MH  - Injections, Intraventricular
MH  - Injections, Spinal
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Morphine/administration & dosage/pharmacology
MH  - Naloxone/administration & dosage/*pharmacology
MH  - Naltrexone/administration & dosage/analogs & derivatives/pharmacology
MH  - Narcotic Antagonists/administration & dosage/*pharmacology
MH  - Pain/physiopathology
MH  - Receptors, Opioid, kappa/drug effects/*physiology
MH  - Spinal Cord/drug effects/*physiology/physiopathology
MH  - Stress, Psychological/*physiopathology
EDAT- 1993/05/21 00:00
MHDA- 1993/05/21 00:01
CRDT- 1993/05/21 00:00
PHST- 1993/05/21 00:00 [pubmed]
PHST- 1993/05/21 00:01 [medline]
PHST- 1993/05/21 00:00 [entrez]
AID - 0006-8993(93)90512-L [pii]
AID - 10.1016/0006-8993(93)90512-l [doi]
PST - ppublish
SO  - Brain Res. 1993 May 21;611(2):264-71. doi: 10.1016/0006-8993(93)90512-l.