PMID- 8392942
OWN - NLM
STAT- MEDLINE
DCOM- 19930820
LR  - 20190721
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 94
IP  - 1
DP  - 1993
TI  - Adenosine, L-AP4, and baclofen modulation of paired-pulse potentiation in the 
      dentate gyrus: interstimulus interval-dependent pharmacology.
PG  - 97-104
AB  - Paired-pulse potentiation of the glutamate-mediated excitatory postsynaptic 
      potential (EPSP) recorded in the dentate gyrus molecular layer is thought to be 
      mediated presynaptically. It is known that the activation of adenosine (A1) and 
      GABAB receptors results in the reduction of glutamate release in the dentate 
      molecular layer via presynaptic mechanisms. To examine possible modulatory roles 
      of these receptors on paired-pulse potentiation, we examined the effects of 
      adenosine and baclofen (a GABAB agonist) on paired-pulse potentiation using 
      extracellular recording from the lateral perforant path in rat hippocampal slices 
      maintained in vitro. We compared these effects with those of 
      L-alpha-amino-4-phosphonobutyric acid (L-AP4) over a wide range of interstimulus 
      intervals (ISIs). L-AP4 enhanced paired-pulse potentiation over the full range of 
      ISIs tested (40-800 ms), whereas adenosine enhanced paired-pulse potentiation 
      only at ISIs of 40-100 ms. In contrast, baclofen reduced paired-pulse 
      potentiation only at ISIs of 400-800 ms. Furthermore, baclofen increased the 
      amplitude of lateral perforant path field potentials, previously reported to be 
      baclofen-insensitive. These results suggest that paired-pulse potentiation can be 
      modulated through the activation of adenosine and baclofen receptors, indicate 
      that this modulation is dependent on ISI, and show that there are at least two 
      pharmacologically separable components of paired-pulse potentiation in the 
      dentate gyrus.
FAU - Kahle, J S
AU  - Kahle JS
AD  - Department of Psychobiology, University of California, Irvine 92717-4550.
FAU - Cotman, C W
AU  - Cotman CW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
RN  - 0 (Aminobutyrates)
RN  - 0 (Glutamates)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Receptors, Purinergic)
RN  - H789N3FKE8 (Baclofen)
RN  - H8B59H10OK (2-amino-4-phosphonobutyric acid)
RN  - K72T3FS567 (Adenosine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adenosine/*pharmacology
MH  - Aminobutyrates/*pharmacology
MH  - Animals
MH  - Baclofen/*pharmacology
MH  - Calcium/physiology
MH  - Dendrites/physiology
MH  - Electric Stimulation
MH  - Evoked Potentials/drug effects
MH  - Glutamates/metabolism
MH  - Hippocampus/cytology/drug effects/*physiology
MH  - In Vitro Techniques
MH  - Male
MH  - Neuromuscular Junction/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, GABA-A/drug effects/physiology
MH  - Receptors, Purinergic/drug effects/physiology
MH  - Stimulation, Chemical
MH  - Synapses/physiology
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1007/BF00230473 [doi]
PST - ppublish
SO  - Exp Brain Res. 1993;94(1):97-104. doi: 10.1007/BF00230473.