PMID- 8393304
OWN - NLM
STAT- MEDLINE
DCOM- 19930826
LR  - 20190821
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 17
IP  - 8
DP  - 1993 Aug
TI  - T-cell lymphoma of the vulva in a renal allograft recipient with associated 
      hemophagocytosis.
PG  - 842-9
AB  - The risk of B-cell lymphoma is greatly increased in transplant patients, whereas 
      T-cell lymphomas have only rarely been reported in these patients. Although 
      T-cell lymphomas in nonimmunosuppressed patients may be associated with either 
      human T-cell lymphotropic virus type I (HTLV-I) or Epstein-Barr virus (EBV), 
      these viruses have not been reported in association with post-transplant T-cell 
      lymphoma. We report a case of T-cell lymphoma of the vulva arising in a renal 
      allograft recipient receiving azathioprine and prednisone. The unusual clinical 
      presentation led to difficulty in diagnosis because of a resemblance to either an 
      infectious process or squamous cell carcinoma. The large cell lymphoma involved 
      the dermis and subcutaneous fat of the vulva and was associated with 
      hemophagocytosis in lymph nodes and bone marrow. The tumor had a mature, aberrant 
      T-cell immunophenotype (CD3+ CD4+ CD7+ CD2- CD5- CD30+). Rearrangement of the 
      T-cell receptor beta and gamma chain genes was found, but there was no evidence 
      of either EBV or HTLV-I genomes. This case adds to the clinical and morphologic 
      spectrum of T-cell lymphomas reported in allograft recipients and suggests that 
      known lymphotropic viruses do not commonly have a role in post-transplant T-cell 
      lymphoma.
FAU - Kaplan, M A
AU  - Kaplan MA
AD  - Department of Pathology, Massachusetts General Hospital, Boston 02114.
FAU - Jacobson, J O
AU  - Jacobson JO
FAU - Ferry, J A
AU  - Ferry JA
FAU - Harris, N L
AU  - Harris NL
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (DNA, Viral)
RN  - 0 (Ki-1 Antigen)
SB  - IM
MH  - Antigens, CD/analysis
MH  - Antigens, Neoplasm/analysis
MH  - DNA, Neoplasm/genetics
MH  - DNA, Viral/analysis/genetics
MH  - Diagnosis, Differential
MH  - Female
MH  - Gene Rearrangement, beta-Chain T-Cell Antigen Receptor/genetics
MH  - Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor/genetics
MH  - Genotype
MH  - Herpesvirus 4, Human/genetics
MH  - Histiocytosis, Non-Langerhans-Cell/*complications/genetics/pathology
MH  - Human T-lymphotropic virus 1/genetics
MH  - Humans
MH  - Immunoblotting
MH  - Immunophenotyping
MH  - Ki-1 Antigen
MH  - *Kidney Transplantation
MH  - Lymphoma, T-Cell/*complications/genetics/pathology
MH  - Middle Aged
MH  - Transplantation, Homologous
MH  - Vulvar Neoplasms/*complications/genetics/pathology
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
AID - 10.1097/00000478-199308000-00010 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 1993 Aug;17(8):842-9. doi: 10.1097/00000478-199308000-00010.