PMID- 8394408
OWN - NLM
STAT- MEDLINE
DCOM- 19930915
LR  - 20190501
IS  - 0022-3050 (Print)
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 56
IP  - 8
DP  - 1993 Aug
TI  - Human herpesvirus 6 and multiple sclerosis: survey of anti-HHV-6 antibodies by 
      immunofluorescence analysis and of viral sequences by polymerase chain reaction.
PG  - 917-9
AB  - A possible involvement of human herpesvirus 6 (HHV-6) infection in the 
      pathogenesis of multiple sclerosis (MS) was investigated. The immunofluorescence 
      analysis of sera from 126 MS patients showed significantly higher anti-HHV-6 
      antibody titres in MS sera than in 500 normal controls. A polymerase chain 
      reaction (PCR) assay of the peripheral blood mononuclear cell (PBMC) DNAs of 31 
      MS patients and 24 normal subjects was positive in one normal control and in one 
      MS patient. The Southern blot analysis indicated an unexpectedly high level of 
      viral sequences in the MS patient, but not in the control. Since viral sequences 
      are rarely present in MS subjects, the high anti-HHV-6 antibody titres found in 
      MS are likely to be related to immune impairment rather than reactivation of a 
      latent infection.
FAU - Sola, P
AU  - Sola P
AD  - Neurological Department, University of Modena, Italy.
FAU - Merelli, E
AU  - Merelli E
FAU - Marasca, R
AU  - Marasca R
FAU - Poggi, M
AU  - Poggi M
FAU - Luppi, M
AU  - Luppi M
FAU - Montorsi, M
AU  - Montorsi M
FAU - Torelli, G
AU  - Torelli G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antibodies, Viral/genetics/*immunology
MH  - Base Sequence
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Herpesvirus 6, Human/*genetics/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Multiple Sclerosis/*microbiology
MH  - Polymerase Chain Reaction
PMC - PMC1015152
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
PMCR- 1993/08/01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
PHST- 1993/08/01 00:00 [pmc-release]
AID - 10.1136/jnnp.56.8.917 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 1993 Aug;56(8):917-9. doi: 10.1136/jnnp.56.8.917.