PMID- 8394794
OWN - NLM
STAT- MEDLINE
DCOM- 19930923
LR  - 20170112
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 11
IP  - 3
DP  - 1993 May-Jun
TI  - Macrophages, synovial tissue and rheumatoid arthritis.
PG  - 331-9
AB  - Macrophage-like synoviocytes originate in the bone marrow, like other mononuclear 
      phagocytes, and are constantly replaced via the circulation. In rheumatoid 
      synovium sections, 80-100% of the synovial lining cells are macrophage-like cells 
      functioning as antigen processing- and antigen-presenting cells to T lymphocytes. 
      Monocyte and lymphocyte traffic into the rheumatoid arthritis (RA) synovium is 
      mediated by adhesion molecules such as endothelial-leukocyte adhesion molecule-1 
      (ELAM-1), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion 
      molecules-1 and -2 (ICAM-1 and ICAM-2), as well as monocyte chemotactic protein 1 
      (MCP-1) and beta 2 integrins (CD11 a,b,c/CD18). Macrophage-like cells in the RA 
      synovium are highly activated based on their morphology, surface class II HLA 
      antigen expression, and synthesis of cytokines such as interleukin-1 beta (IL-1 
      beta), tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), 
      granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage CSF, and 
      transforming growth-factor beta (TGF-beta). Evidence for type 1 (higher affinity) 
      and type 2 (lower affinity) androgen (ARs) and estrogen receptors (ERs) on 
      macrophage-like synoviocytes in either male or female synovial samples from both 
      RA patients and controls has been reported. In particular, ERs have also been 
      found on CD8+CD29+ CD45R0+ T lymphocytes (memory), infiltrating rheumatoid 
      synovial tissues. Sex hormones have been found to influence macrophage activity 
      in experimental and clinical conditions such as RA. Generally estrogens have 
      immunostimulatory effects, whereas androgens are immuno-suppressive.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Cutolo, M
AU  - Cutolo M
AD  - Department of Internal Medicine, University of Genova, Italy.
FAU - Sulli, A
AU  - Sulli A
FAU - Barone, A
AU  - Barone A
FAU - Seriolo, B
AU  - Seriolo B
FAU - Accardo, S
AU  - Accardo S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytokines)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Arthritis, Rheumatoid/metabolism/*pathology
MH  - Cell Adhesion Molecules/metabolism
MH  - Cell Communication
MH  - Cytokines/metabolism
MH  - Gonadal Steroid Hormones/metabolism
MH  - Humans
MH  - Lymphocytes/physiology
MH  - Macrophages/metabolism/*pathology/physiology
MH  - Receptors, Cell Surface/metabolism
MH  - Reference Values
MH  - Synovial Membrane/metabolism/*pathology
RF  - 87
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
PST - ppublish
SO  - Clin Exp Rheumatol. 1993 May-Jun;11(3):331-9.