PMID- 8395120
OWN - NLM
STAT- MEDLINE
DCOM- 19930922
LR  - 20071114
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 196
IP  - 1
DP  - 1993 Sep
TI  - Sequence similarity between the long terminal repeat coding regions of 
      mammary-tumorigenic BALB/cV and renal-tumorigenic C3H-K strains of mouse mammary 
      tumor virus.
PG  - 303-8
AB  - The long terminal repeat (LTR) of mouse mammary tumor virus (MMTV) encodes a 
      protein which functions as a superantigen. The BALB/cV strain differs from other 
      exogenous MMTVs antigenically, biochemically, on the basis of restriction 
      fragment analysis, and by the specificity of its superantigen for V beta 2+ T 
      cells. In order to elucidate the origin of the BALB/cV virus and to better 
      understand the interaction of its superantigen with the T cell receptor, we have 
      determined the nucleotide sequence of the BALB/cV LTR open reading frame, 
      including 93 bases downstream of the translation termination site. The encoded 
      protein's C-terminal portion, thought to control superantigenic specificity, is 
      identical to the C3H-K strain of MMTV, isolated from a rare kidney 
      adenocarcinoma. The remainder of the coding sequence is highly related to many 
      MMTV strains. Like other MMTV strains, the BALB/cV LTR maintains intact an 18 
      base pair sequence, located downstream of the translational termination site, 
      which is lacking in the C3H-K LTR. Sequence comparison between the BALB/cV LTR 
      and other MMTV strains indicates that the most likely origin for the BALB/cV open 
      reading frame sequence is a recombination event involving the endogenous provirus 
      mtv-6.
FAU - Kang, J J
AU  - Kang JJ
AD  - Department of Biology, Villanova University, Pennsylvania 19085.
FAU - Schwegel, T
AU  - Schwegel T
FAU - Knepper, J E
AU  - Knepper JE
LA  - eng
SI  - GENBANK/L13149
GR  - CA52853/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (DNA, Viral)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Adenocarcinoma/*microbiology
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - DNA, Viral
MH  - Kidney Neoplasms/*microbiology
MH  - Mammary Tumor Virus, Mouse/*genetics/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Receptors, Antigen, T-Cell, alpha-beta/immunology
MH  - *Repetitive Sequences, Nucleic Acid
MH  - Sequence Homology, Amino Acid
MH  - Viral Proteins/*genetics/immunology
EDAT- 1993/09/01 00:00
MHDA- 1993/09/01 00:01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 1993/09/01 00:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
AID - S0042-6822(83)71480-7 [pii]
AID - 10.1006/viro.1993.1480 [doi]
PST - ppublish
SO  - Virology. 1993 Sep;196(1):303-8. doi: 10.1006/viro.1993.1480.