PMID- 8395488
OWN - NLM
STAT- MEDLINE
DCOM- 19930930
LR  - 20131121
IS  - 0332-3102 (Print)
IS  - 0332-3102 (Linking)
VI  - 86
IP  - 4
DP  - 1993 Jul-Aug
TI  - The effects of lisinopril on serum catecholamine concentrations both at rest and 
      on exercise in patients with congestive cardiac failure. A double blind, placebo 
      controlled, parallel group study.
PG  - 134-5
AB  - Patients with congestive cardiac failure have elevated sympathetic activity at 
      rest which contributes to the pathophysiology of this syndrome. In addition, the 
      sympathetic response to exercise in these patients is abnormal. Sympathetic 
      activity is accurately reflected by serum noradrenaline levels. In a 
      double-blind, placebo-controlled, parallel group study, 16 patients of New York 
      Heart Association (NYHA) functional class II, stabilised on optimum doses of 
      diuretics were randomised into two equal groups, to receive either low-dose 
      Lisinopril, an orally active angiotensin converting enzyme (ACE) inhibitor, or 
      matching placebo, over a 12 week period. At the end of the 12 week treatment 
      phase, there was no significant change in noradrenaline levels at rest (p = 0.33) 
      mid exercise (p = 0.17), or peak exercise (p = 0.69), in the lisinopril group. 
      Both lisinopril and placebo groups improved subjectively as assessed by change in 
      NYHA grade, (p < 0.01 for placebo and p < 0.001 for those given lisinopril). 
      Exercise duration improved significantly in the lisinopril group (p = 0.0296), 
      but not in the placebo group after treatment. Low dose lisinopril is of use in 
      congestive cardiac failure even in the absence of measurable changes in 
      sympathetic tone.
FAU - Fahy, G
AU  - Fahy G
AD  - Dept of Cardiology, Adelaide Hospital, Dublin.
FAU - Deb, B
AU  - Deb B
FAU - Robinson, K
AU  - Robinson K
FAU - Graham, I
AU  - Graham I
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Ireland
TA  - Ir Med J
JT  - Irish medical journal
JID - 0430275
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Dipeptides)
RN  - 0 (Placebos)
RN  - E7199S1YWR (Lisinopril)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Angiotensin-Converting Enzyme Inhibitors/administration & dosage/*therapeutic use
MH  - Arrhythmias, Cardiac/prevention & control
MH  - Dipeptides/administration & dosage/*therapeutic use
MH  - Double-Blind Method
MH  - Exercise Test
MH  - Female
MH  - Heart Failure/blood/*drug therapy/physiopathology
MH  - Humans
MH  - Lisinopril
MH  - Male
MH  - Middle Aged
MH  - Norepinephrine/*blood
MH  - Physical Exertion/*physiology
MH  - Placebos
MH  - Rest/*physiology
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
PST - ppublish
SO  - Ir Med J. 1993 Jul-Aug;86(4):134-5.