PMID- 8396070
OWN - NLM
STAT- MEDLINE
DCOM- 19931005
LR  - 20190830
IS  - 0300-8126 (Print)
IS  - 0300-8126 (Linking)
VI  - 21
IP  - 3
DP  - 1993 May-Jun
TI  - Improvement of serological diagnosis of human cytomegalovirus infection in renal 
      transplant recipients by testing for specific immunoglobulin E by ELISA.
PG  - 158-63
AB  - The kinetics of human cytomegalovirus (HCMV)-specific immunoglobulin E (IgE), M 
      (IgM), A (IgA) and G (IgG) were studied in 421 sera obtained from 19 renal 
      allograft recipients by enzyme-linked immunosorbent assay (ELISA). Cytomegalic 
      inclusion disease (CID) occurred in 11 (57.9%) patients. HCMV infection was 
      diagnosed in all (100%) of these patients by testing for specific IgE. In 
      contrast, increased levels of IgM and IgA class antibody against HCMV were 
      detected in only 45.5% and 18.2% patients suffering from primary or recurrent 
      HCMV infection, respectively. Concerning the time interval between the onset of 
      clinical symptoms and the first positive test, no significant differences in the 
      kinetics of HCMV-specific immunoglobulins E, M, A and G were observed. Elevated 
      specific IgE levels persisted for longer time intervals than the other 
      immunoglobulin classes. As shown by the present study, specific IgE proved to be 
      a more reliable serologic marker than IgM and IgA for the serologic detection of 
      HCMV infection in renal allograft recipients.
FAU - Weber, B
AU  - Weber B
AD  - Abteilung fur Medizinische Virologie, Zentrum der Hygiene, Universitatsklinikum 
      Frankfurt, Germany.
FAU - Stemmler, A
AU  - Stemmler A
FAU - Ernst, W
AU  - Ernst W
FAU - Scheuerman, E H
AU  - Scheuerman EH
FAU - Braun, W
AU  - Braun W
FAU - Doerr, H W
AU  - Doerr HW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Infection
JT  - Infection
JID - 0365307
RN  - 0 (Antibodies, Viral)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/*blood
MH  - Biomarkers/blood
MH  - Cytomegalovirus/*immunology/isolation & purification
MH  - Cytomegalovirus Infections/*immunology
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Humans
MH  - Immunoglobulin A/blood
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - *Kidney Transplantation
MH  - Male
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
AID - 10.1007/BF01710536 [doi]
PST - ppublish
SO  - Infection. 1993 May-Jun;21(3):158-63. doi: 10.1007/BF01710536.