PMID- 8396171
OWN - NLM
STAT- MEDLINE
DCOM- 19931005
LR  - 20220310
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 13
IP  - 9
DP  - 1993 Sep
TI  - Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in 
      the adult hippocampus.
PG  - 4001-14
AB  - Brain-derived neurotrophic factor (BDNF) and its signal transducing receptor, the 
      TrkB tyrosine protein kinase, are expressed at high levels in the hippocampus of 
      the adult brain, suggesting a role for BDNF mechanisms in neuronal plasticity. To 
      test this hypothesis, we used defined lesions of perforant path and 
      fimbria-fornix, two major hippocampal afferents, to remove synapses on dendrites 
      of dentate gyrus granule cells and pyramidal cells of Ammon's horn and induce 
      synaptic rearrangements. These combined lesions remove afferent connections from 
      entorhinal cortex and septum and produce massive sprouting of axons of the 
      commissural/associational pathways into the molecular layer of the hippocampal 
      dentate gyrus. At days 1, 3, and 6, the lesions decreased BDNF mRNA expression 
      ipsilaterally to approximately 50% of control, with complete recovery at 14 d. 
      The lesions did not alter trkB mRNA levels in neuronal layers of the hippocampus; 
      however, they resulted in a pronounced induction of trkB mRNA expression in 
      hippocampal non-neuronal cells 6-14 d after lesioning. The induction corresponded 
      in time and place to the synaptic reorganization in the lesioned hippocampus. The 
      mRNA species newly induced by the lesions corresponded to those transcripts 
      encoding the noncatalytic TrkB receptor isoform that lacks the cytoplasmic 
      protein kinase domain. Expression of mRNAs coding for neurotrophin-3 and the TrkC 
      tyrosine protein kinase were not altered by the lesions. The findings suggest 
      that truncated noncatalytic TrkB molecules expressed on the surface of glial 
      cells play an important role in plasticity of the adult brain, possibly 
      regulating the concentration of bioactive neurotrophins or the responsiveness of 
      neurotrophin receptors. Alternatively, they may play a role in presenting 
      neurotrophin molecules to growing axons.
FAU - Beck, K D
AU  - Beck KD
AD  - Division of Neurogerontology, Andrus Gerontology Center, University of Southern 
      California, Los Angeles 90089-0191.
FAU - Lamballe, F
AU  - Lamballe F
FAU - Klein, R
AU  - Klein R
FAU - Barbacid, M
AU  - Barbacid M
FAU - Schauwecker, P E
AU  - Schauwecker PE
FAU - McNeill, T H
AU  - McNeill TH
FAU - Finch, C E
AU  - Finch CE
FAU - Hefti, F
AU  - Hefti F
FAU - Day, J R
AU  - Day JR
LA  - eng
GR  - AG10480/AG/NIA NIH HHS/United States
GR  - NS22933/NS/NINDS NIH HHS/United States
GR  - NS30426/NS/NINDS NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Antisense)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Sulfur Radioisotopes)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
GS  - trcK
GS  - trkB
MH  - Animals
MH  - Autoradiography
MH  - Axons/metabolism/*physiology/ultrastructure
MH  - Brain-Derived Neurotrophic Factor
MH  - Gene Expression
MH  - Hippocampus/*metabolism/physiology/ultrastructure
MH  - In Situ Hybridization
MH  - Male
MH  - Membrane Glycoproteins/analysis/*biosynthesis
MH  - Membrane Proteins/analysis/*biosynthesis
MH  - Nerve Growth Factors/biosynthesis
MH  - Nerve Tissue Proteins/biosynthesis
MH  - Neurotrophin 3
MH  - Protein-Tyrosine Kinases/analysis/*biosynthesis
MH  - RNA, Antisense
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptor, trkB
MH  - Receptor, trkC
MH  - Receptors, Cell Surface/analysis/*biosynthesis
MH  - Sulfur Radioisotopes
PMC - PMC6576456
EDAT- 1993/09/01 00:00
MHDA- 1993/09/01 00:01
PMCR- 1994/03/01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 1993/09/01 00:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
PHST- 1994/03/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.13-09-04001.1993 [doi]
PST - ppublish
SO  - J Neurosci. 1993 Sep;13(9):4001-14. doi: 10.1523/JNEUROSCI.13-09-04001.1993.