PMID- 8396461
OWN - NLM
STAT- MEDLINE
DCOM- 19931008
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 4
IP  - 7
DP  - 1993 Jul
TI  - The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the 
      dentate gyrus.
PG  - 895-8
AB  - We have investigated the expression of the mRNAs for brain-derived neurotrophic 
      factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3) and 
      neurotrophin-4 (NT-4) in the hippocampus before and after induction of long term 
      potentiation (LTP) of synaptic transmission in the dentate gyrus through 
      stimulation of the perforant path (PP). A unilateral PP stimulation produced a 
      bilateral increase in the mRNA for both BDNF and NGF in granular neurones of the 
      dentate gyrus but not in other neurones in the hippocampus. The mRNA for 
      neurotrophin-3 (NT-3) was bilaterally decreased by LTP but that of NT-4 remained 
      at the basal level. These results suggest that individual neurotrophic factors 
      may play different roles in neuronal plasticity.
FAU - Castren, E
AU  - Castren E
AD  - Department of Neurochemistry, Max Planck Institute for Psychiatry, Martinsried, 
      Germany.
FAU - Pitkanen, M
AU  - Pitkanen M
FAU - Sirvio, J
AU  - Sirvio J
FAU - Parsadanian, A
AU  - Parsadanian A
FAU - Lindholm, D
AU  - Lindholm D
FAU - Thoenen, H
AU  - Thoenen H
FAU - Riekkinen, P J
AU  - Riekkinen PJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - Brain-Derived Neurotrophic Factor
MH  - Electric Stimulation
MH  - Hippocampus/*metabolism/physiology
MH  - In Situ Hybridization
MH  - Male
MH  - Nerve Fibers/physiology
MH  - Nerve Growth Factors/*biosynthesis
MH  - Nerve Tissue Proteins/*biosynthesis
MH  - Neuronal Plasticity/*physiology
MH  - Neurons/physiology
MH  - Neurotrophin 3
MH  - Protein-Tyrosine Kinases/biosynthesis
MH  - RNA, Messenger/*biosynthesis
MH  - Rats
MH  - Rats, Wistar
MH  - Synapses/physiology
MH  - Synaptic Transmission/physiology
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
AID - 10.1097/00001756-199307000-00014 [doi]
PST - ppublish
SO  - Neuroreport. 1993 Jul;4(7):895-8. doi: 10.1097/00001756-199307000-00014.