PMID- 8396680
OWN - NLM
STAT- MEDLINE
DCOM- 19931012
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 67
IP  - 10
DP  - 1993 Oct
TI  - Specificity analysis of human CD4+ T-cell clones directed against human 
      herpesvirus 6 (HHV-6), HHV-7, and human cytomegalovirus.
PG  - 6259-64
AB  - In order to clarify antigenic variations among various isolates of human 
      herpesvirus 6 (HHV-6) and cross-reactivity among HHV-6, HHV-7, and human 
      cytomegalovirus (HCMV) in the T-cell immune response, the antigenic specificity 
      of the proliferative response mediated by 232 CD4+ human T-cell clones directed 
      against HHV-6, HHV-7, or HCMV was examined. The results obtained were as follows. 
      (i) Although the majority of T-cell clones directed against HHV-6 proliferated in 
      response to stimulation with all strains of HHV-6 used (U1102, Z29, SF, and HST), 
      7% (8 of 122) of the T-cell clones showed distinct patterns of proliferative 
      response against strain U1102 (group A) and other strains of HHV-6 (group B). 
      (ii) Of 99 T-cell clones, 71 showed a distinct proliferative response to HHV-6 
      and HHV-7, whereas 28 proliferated in response to stimulation with both HHV-6 and 
      HHV-7. (iii) A small number of T-cell clones (9 of 232) showed cross-reactivity 
      against HHV-6 and HCMV, and 2 of the 232 clones were reactive with HCMV as well 
      as with HHV-6 and HHV-7. (iv) The specificity of gamma interferon production by 
      T-cell clones following the stimulation with virus antigen was identical to that 
      of their proliferative response. These data thus indicate the presence of 
      antigenic variations among isolates of HHV-6 and also epitopes common to HHV-6 
      and HHV-7 and to HHV-6, HHV-7, and HCMV which are recognized by CD4+ T cells.
FAU - Yasukawa, M
AU  - Yasukawa M
AD  - First Department of Internal Medicine, Ehime University School of Medicine, 
      Japan.
FAU - Yakushijin, Y
AU  - Yakushijin Y
FAU - Furukawa, M
AU  - Furukawa M
FAU - Fujita, S
AU  - Fujita S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Antigens, Viral)
RN  - 0 (CD4 Antigens)
RN  - 82115-62-6 (Interferon-gamma)
RN  - VC2W18DGKR (Thymidine)
SB  - IM
MH  - Antigens, Viral/immunology
MH  - CD4 Antigens/*immunology
MH  - Cells, Cultured
MH  - Clone Cells
MH  - Cross Reactions
MH  - Cytomegalovirus/*immunology
MH  - Herpesvirus 6, Human/*immunology
MH  - Herpesvirus 7, Human/*immunology
MH  - Humans
MH  - Interferon-gamma/biosynthesis
MH  - Lymphocyte Activation
MH  - T-Lymphocyte Subsets/*immunology
MH  - Thymidine/metabolism
PMC - PMC238049
EDAT- 1993/10/01 00:00
MHDA- 1993/10/01 00:01
PMCR- 1993/10/01
CRDT- 1993/10/01 00:00
PHST- 1993/10/01 00:00 [pubmed]
PHST- 1993/10/01 00:01 [medline]
PHST- 1993/10/01 00:00 [entrez]
PHST- 1993/10/01 00:00 [pmc-release]
AID - 10.1128/JVI.67.10.6259-6264.1993 [doi]
PST - ppublish
SO  - J Virol. 1993 Oct;67(10):6259-64. doi: 10.1128/JVI.67.10.6259-6264.1993.